Silicon oxycarbide glasses for blood-contact applications
Source abstract
Abstract
Silicon oxycarbide (SiOxCy) glass compositions are shown to exhibit a variable propensity to contact activate coagulation of whole human blood plasma that depends on X:Y surface stoichiometry. SiOxCy exhibit activation properties similar to pyrolytic carbon (PC) over a broad range of X:Y ratios. Surface composition of SiOxCy glass powders prepared by pyrolysis of thermosetting polysilsequioxanes roughly correlated with total carbon concentration of precursor resins and could be significantly modified by etching in alkaline solutions. Results suggest that SiOxCy may offer unique properties as a substitute for PC in medical-device applications demanding excellent tribological properties, such as artificial heart valves.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Diamond and Carbon-based Materials Research · Advanced ceramic materials synthesis · Metal and Thin Film Mechanics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (30)
Show source-provided references
1. Carbon in biomedical devices
2. Adhesive protein expression on endotheial cells after contact in vitro with polyethylene tereththalate coated with pyrolytic carbon10.1016/0142-9612(95)98128-2 ↗
3. Biocompatibility of the surface layer of pyrolytic carbon10.1016/S0040-6090(03)00309-2 ↗
4. Platelet and coagulation factor variations induced in vitro by polyethylene terephthalate (Dacron) coated with pyrolytic carbon10.1016/0142-9612(95)94903-X ↗
5. Mechanical heart valves: 50 years of evolution10.1016/j.athoracsur.2003.09.002 ↗
6. Preparation and structure of silicon oxycarbide glasses derived from polysiloxane precursors10.1007/BF02436860 ↗
7. Silicon oxycarbide glasses10.1023/A:1008765829012 ↗
8. Pyrolytic decomposition of preceramic organo polysiloxanes. Innovative processing and synthesis of ceramics
9. Silicon oxycarbide glasses derived from polymer precursors10.1023/A:1008639727164 ↗
10. Transmission electron microscopy and electron energy-loss spectroscopy study of nonstoichiometric silicon–carbon–oxygen glasses10.1111/j.1151-2916.2001.tb00986.x ↗
11. Creep viscosity and stress relaxation of gel-derived silicon oxycarbide glasses10.1111/j.1151-2916.2001.tb00789.x ↗
12. Surface damage resistance of gel-derived oxycarbide glasses: hardness, toughness, and scratchability10.1111/j.1151-2916.2001.tb00991.x ↗
13. Microstructural and mechanical characterization of sol gel-derived Si–O–C glasses10.1016/S0955-2219(01)00537-4 ↗
14. Chemical durability of silicon oxycarbide glasses10.1111/j.1151-2916.2002.tb00308.x ↗
15. Song SR. Chemical vapor deposition of silicon oxycarbide thin films by oxy-carbonization of SiH4–CO2–C2H4 mixtures. PhD dissertation, Pennsylvania State University, University Park, PA, 1999.
16. Polymer derived engineering ceramics10.1002/1527-2648(200006)2:6<339::AID-ADEM339>3.0.CO;2-K ↗
17. Ceramic foams from preceramic polymers10.1007/s10019-002-0209-z ↗
18. Preparation of silicon oxycarbide glass fibers from organically modified silicates10.1023/A:1004832305979 ↗
19. Ceramic microtubes from preceramic polymers10.1111/j.1151-2916.2003.tb03413.x ↗
20. Preparation of silicon oxycarbide ceramic films by pyrolysis of polymethyl- and polyvinylsilsesquioxanes10.1023/A:1008765103113 ↗
21. Silicon oxycarbide formation on SiC surfaces and at the SiC/SiO2 interface10.1116/1.580951 ↗
22. Brown · 1980
23. High affinity binding of factor FXIIa to an electronegative surface controls the rates of factor XII and Prekallirien activation in vitro10.1016/S0049-3848(98)00207-2 ↗
24. Procoagulant stimulus processing by the intrinsic pathway of blood plasma coagulation10.1016/j.biomaterials.2004.08.008 ↗
25. Contact activation of the plasma coagulation cascade. 1. Procoagulant surface energy and chemistry10.1002/jbm.820290813 ↗
26. Contact activation of the plasma coagulation cascade. 3. Biophysical aspects of thrombin-binding antocoagulants10.1002/(SICI)1097-4636(199804)40:1<92::AID-JBM11>3.0.CO;2-M ↗
27. High temperature stability of sol–gel-derived SiOC glasses10.1023/A:1008775830830 ↗
28. Contact activation of the plasma coagulation cascade. 2. Protein adsorption on procoagulant surfaces10.1002/jbm.820290814 ↗
29. Structure and reactivity of water at biomaterial surfaces10.1016/S0001-8686(97)00040-7 ↗
30. Interfacial chemistry in biomaterials science