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3D printing is reshaping ophthalmic biomaterials, tissue models, implants, biosensors, and drug-delivery systems, but its clinical value depends on matching each printing strategy to ocular-specific requirements rather than on printing capability alone. This review classifies ophthalmic 3D printing into extrusion-based, inkjet-based, electric field-assisted, and light-assisted …
Tissue-engineered skin substitutes (TESS) represent a key therapeutic option for extensive cutaneous injuries when autologous grafting is limited; however, current constructs lack skin appendages, particularly hair follicles, resulting in incomplete functional and aesthetic restoration. A central barrier to engineering follicular structures within TESS is the rapid loss of hair…
Despite significant progress in our understanding of stomach physiology and the identification of key etiological factors, peptic ulcer disease continues to be a prevalent condition with global health implications. Current therapeutic interventions primarily target systemic pharmacological pathways, focusing on the suppression of acid secretion and the management of Helicobacte…
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Current osmotic tissue expanders suffer from protein adsorption, bacterial colonization, and excessive fibrotic encapsulation that compromise device performance. In this study, we synthesized zwitterionic hydrogels using methyl methacrylate, n-vinyl pyrrolidone, and varying percentages (5-50%) of [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) to sim…
Distraction osteogenesis (DO) remains limited by prolonged consolidation and delayed bone union. This study evaluated whether a biodegradable, bone morphogenetic protein-2 (BMP-2)-releasing intramedullary implant (IMI) could enhance bone regenerate formation in a rat monofocal femoral lengthening model. We developed a Hybrid Tissue Engineering Construct (HyTEC) comprising a 3D-…
Biomaterial scaffolds hold great potential for addressing tumor recurrence and tissue defects following surgical tumor resection; however, personalized therapy remains a critical barrier to their clinical translation. To address this issue, we developed an autologous tumor cell-integrated microporous annealed particle (MAP) scaffold co-delivering an immune adjuvant and an indol…
Mechanical signals are essential for bone homeostasis and regeneration. Reduced mechanical stimulation, such as that occurring during fractures, paralysis, or aging, leads to bone loss and impaired osseous repair. However, effective clinical strategies that restore osteogenesis by reactivating mechanotransduction remain limited. In this study, we investigated downstream pathway…
Native tissues and organs exhibit intrinsic heterogeneity in their structural, compositional, and functional properties, which poses significant challenges towards the development of effective functional substitutes. Multi-material three-dimensional (3D) bioprinting has emerged as a promising strategy to address these challenges by enabling enhanced spatial control over the dep…
Integrating acellular scaffolds with cell-laden hydrogels holds great potential for engineering soft tissue constructs with structural integrity and uniform cellular distribution. However, achieving sustained and viable tissue regeneration remains a challenge due to poor nutrient diffusion and vascularization in bulk hydrogels. We propose to incorporate cell-laden microgels int…
Mg alloys have become a new generation of biodegradable medical materials due to their good biocompatibility. However, their rapid corrosion rate in physiological environments and the mismatch between their degradation rate and tissue reconstruction pose challenges for clinical applications. To improve the corrosion resistance and biocompatibility of Mg alloys, drug-loaded corr…
Thrombosis drives myocardial infarction, acute ischemic stroke and pulmonary embolism, yet more than half of patients undergoing mechanical thrombectomy fail to achieve functional independence, and residual thrombus is detected in up to 91% of cases after catheter-directed thrombolysis. These persistent clinical failures reflect a fundamental gap: thrombus removal is not merely…
Thermosensitive hydrogels derived from thermogelling polymers have garnered growing interest as injectable biomaterials. However, conventional thermosensitive hydrogels often suffer from inadequate mechanical robustness and limited in vivo persistence. To address these issues, a series of amphiphilic poly(2-ethyl-2-oxazoline)-poly(L-alanine) (PEOz-PAla) copolymers are synthesiz…
Glioblastoma (GBM) as the most malicious primary brain tumor is infiltrative and often unresectable, which coupled with a profoundly immunosuppressive tumor microenvironment (TME) lead to a poor prognosis for patients. Here, we developed a golden vesicular nanoadjuvant (Au/TLR3-V) comprising gold nanoclusters and TLR3 agonist poly(I:C), formulated within an injectable hydrogel …
Viper fangs represent one of the most mechanically sophisticated biological penetration devices found in nature. Despite extensive interest in their venom-delivery function, a comprehensive characterization of the structure, composition, and biomechanics of neotropical viper fangs remains lacking. This study presents the first integrated analysis of the tubular fangs of three L…
Effective regeneration of skeletal muscle with highly aligned fiber architecture remains a significant challenge in tissue engineering. Structural alignment of muscle constructs along with mechanical integrity are crucial for effective engineering of grafts and microphysiological systems. This study introduced a composite microfiber-hydrogel platform using melt electrowriting (…
Indwelling medical devices, such as intravenous and urinary catheters, have significantly enhanced patient care and greatly improved treatment outcomes. Despite rapid advances in medical devices, infection and thrombosis continue to pose major challenges to device functionality and integrity. Given that current treatments often involve systemic administration of antibiotics and…
Inhalable nanodelivery faces a tricky and paradoxical interfacial challenge: penetrating mucus requires nanoparticles to be negatively charged or neutral to avoid electrostatic trapping, whereas targeting and disrupting bacterial biofilms strongly relies on positive charges. To address this, we developed inhalable polymer nanoparticles featuring gradient spatial protonation and…
Background/objective The development of regenerative therapies for osteoarthritis and intervertebral disc degeneration requires non-destructive methods to spatiotemporally monitor extracellular matrix (ECM) synthesis. This study aimed to establish a method for the use of bioorthogonal click chemistry for longitudinal and spatially resolved tracking of newly synthesized proteogl…
Many natural and biological materials exhibit intricate hierarchical architectures to effectively manage crack propagation and fracture. This enables them to overcome the critical trade-off between strength and toughness that plagues modern ceramics and ceramic composites. This study investigates the microstructure of enamel from five different mammalian species to inform the s…