Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy
Source abstract
Abstract
We used high-resolution Kelvin probe force microscopy (KPFM) to investigate the immobilization of a prostate specific antigen (PSA) antibody by measuring the surface potential (SP) on a MoS2 surface over an extensive concentration range (1 pg/ml–100 μg/ml). After PSA antibody immobilization, we demonstrated that the SP on the MoS2 surface characterized by KPFM strongly correlated to the electrical signal of a MoS2 bioFET. This demonstration can not only be used to optimize the immobilization conditions for captured molecules, but can also be applied as a diagnostic tool to complement the electrical detection of a MoS2 FET biosensor.
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Research context
OpenAlex topics: Force Microscopy Techniques and Applications · Nanowire Synthesis and Applications · Mechanical and Optical Resonators
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Yonsei University 1 Department of Biomedical Engineering, , Wonju 26493, South Korea
Kyung Hee University 2 Multi-Functional Nano/Bio Electronics Laboratory, , Gyeonggi 446-701, South Korea
Korea Institute of Science and Technology 3 Center for Bionics, Biomedical Research Institute, , Seoul 02792, South Korea
Korea University 4 Department of Bio-convergence Engineering, , Seoul 136-701, South Korea
Funding
Yonsei University Future-leading Research Initiative of 2015 · National Research Foundation of Korea
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