journal article·2026-02-01Open access

High-Tc SQUID-based ultra-low field MRI in unshielded environments

Shu-Hsien Liao, Han-Sheng Huang

AIP Advances· Volume 16· Issue 2

Abstract

A high-performance MRI based on high-Tc SQUID and flux coupling at ultralow magnetic fields is reported in this work. The technique of NMR/MRI was optimized to study MRI of water phantoms and fingers. An SNR of 62 in image contrast was achieved for a water column of 200 μL at magnetic fields of 98 μT. The MRI showed high image contrast and demonstrated a spatial resolution of 2 mm for samples in magnetically unshielded environments. This resolution is comparable to the current state-of-the-art values (typically 2.0–3.0 mm) reported for SQUID-based ULF MRI systems. A clear image of fingers was demonstrated for the first time using high-Tc SQUIDs, which shows promise for biological or clinical applications.
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Research context

OpenAlex topics: Advanced MRI Techniques and Applications · Atomic and Subatomic Physics Research · NMR spectroscopy and applications

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Affiliations

Institute of Electro-Optical Engineering, National Taiwan Normal University , Taipei 116,

Funding

National Science and Technology Council · National Taiwan Normal University

References (24)

Show source-provided references
1. Liquid-state NMR and scalar couplings in microtesla magnetic fields10.1126/science.1069280 ↗
2. Microtesla MRI with a superconducting quantum interference device10.1073/pnas.0402382101 ↗
3. Nuclear magnetic resonance in the nanotesla range10.1063/1.2006981 ↗
4. SQUID detected NMR in microtesla magnetic fields10.1016/j.jmr.2004.05.015 ↗
5. Multi-channel SQUID system for MEG and ultra-low-field MRI10.1109/tasc.2007.898198 ↗
6. SQUID-detected MRI at 132 μT with T1-weighted contrast established at 10 μT-300 mT10.1002/mrm.20316 ↗
7. SQUID-detected microtesla MRI in the presence of metal10.1016/j.jmr.2005.11.005 ↗
8. SQUID-detected ultra-low field MRI10.1016/j.jmr.2013.02.009 ↗
9. Enhancement of nuclear magnetic resonance with prepolarization field in microtesla magnetic field detected with high-Tc superconducting quantum interference device10.1063/1.2216904 ↗
10. Microtesla NMR and high resolution MR imaging using High-Tc SQUIDs10.1109/TASC.2013.2237732 ↗
11. High-Tc superconducting quantum interference device recordings of spontaneous brain activity: Towards high-Tc magnetoencephalography10.1063/1.3698152 ↗
12. Magnetoencephalography using high temperature rf SQUIDs10.1007/bf01128694 ↗
13. High-Tc DC SQUIDs for magnetoencephalography10.1109/tasc.2012.2229094 ↗
14. Characterization of tumors using SQUID-detected nuclear magnetic resonance and imaging10.1063/1.3530124 ↗
15. Optimization of the detection coil of high-Tc superconducting quantum interference device-based nuclear magnetic resonance for discriminating a minimum amount of liver tumor of rats in microtesla fields10.1063/1.4817886 ↗
16. Signal analysis and liver tumor discrimination by using a High-Tc SQUID-based low-field NMR system in hospital10.1109/TASC.2015.2393633 ↗
17. Use of a high-Tc SQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate10.1088/1748-0221/7/06/p06005 ↗
18. Low-field nuclear magnetic resonance and magnetic resonance imaging using a high-Tc SQUID for tumor detection10.1109/tasc.2010.2083617 ↗
19. Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in low magnetic fields10.1063/1.4774291 ↗
20. Image formation by induced local interactions: Examples employing nuclear magnetic resonance10.1038/242190a0 ↗
21. 2000
22. Measurements of T1-relaxation in ex vivo prostate tissue at 132 µT10.1002/mrm.24177 ↗
23. Parallel MRI at microtesla fields10.1016/j.jmr.2008.02.015 ↗
24. In vivo screening of hepatocellular carcinoma using AC susceptibility of anti-alpha fetoprotein-activated magnetic nanoparticles10.1371/journal.pone.0046756 ↗