Reaction field-dependent spin-correlated radical pair model: A new insight into liposomal drug-delivery system
Source abstract
Abstract
This work was focused on new drug-release potentials associated with phospholipid-bilayer structures and magnetic field effects, as it were, a liposomal nanoparticle model with reaction field-dependent spin-correlated radical pair mechanisms. The release potentials were evaluated by measuring the spectral changes after photoexcitation of anticancer flutamide in the liposomal membrane, as well as utilizing 31P-NMR signals which refers to a paramagnetic Eu-induced shift technique. As it turned out, a close connection between magnetic field effects and Eu3+ osmosis was observed depending on physicochemical reaction field, magnetic field strength, and so on. Reaction field-dependent spin-correlated radical pair mechanisms will find a new light in the future of liposomal drug-delivery system. Not only that, but this innovative methodology must be one of the most adaptable techniques, which may be able to analogize the ultrastructural state of molecular nanoenvironments swiftly and easily.
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Research context
OpenAlex topics: Electron Spin Resonance Studies · Protein Interaction Studies and Fluorescence Analysis · Spectroscopy and Quantum Chemical Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Electrical and Electronic Engineering, Graduate School of Engineering, Tokyo Denki University , 5 Senju-Asahi-Cho, Adachi-ku, Tokyo 120-8551, Japan
Funding
Japan Society for the Promotion of Science · Daiwa Securities Health Foundation · Precise Measurement Technology Promotion Foundation · Terumo Foundation for Life Sciences and Arts
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