journal article·2013-04-01Open access

Low dose hard x-ray contact microscopy assisted by a photoelectric conversion layer

Andrew Gomella, Eric W. Martin, Susanna K. Lynch, Nicole Y. Morgan, Han Wen

AIP Advances· Volume 3· Issue 4

Abstract

Hard x-ray contact microscopyprovides images of dense samples at resolutions of tens of nanometers. However, the required beam intensity can only be delivered by synchrotron sources. We report on the use of a gold photoelectric conversion layer to lower the exposure dose by a factor of 40 to 50, allowing hard x-ray contact microscopy to be performed with a compact x-ray tube. We demonstrate the method in imaging the transmission pattern of a type of hard x-raygrating that cannot be fitted into conventional x-ray microscopes due to its size and shape. Generally the method is easy to implement and can record images of samples in the hard x-ray region over a large area in a single exposure, without some of the geometric constraints associated with x-ray microscopes based on zone-plate or other magnifying optics.
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Research context

OpenAlex topics: Advanced X-ray Imaging Techniques · Advanced Electron Microscopy Techniques and Applications · Force Microscopy Techniques and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Institutes of Health 1 Imaging Physics Laboratory, Biophysics and Biochemistry Center,National Heart, Lung and Blood Institute, ,Bethesda, MD, 20892, USA

National Institutes of Health 2 Intramural Research Programs, National Institute of Biomedical Imaging and Bioengineering, , Bethesda, MD, 20892, USA

Funding

National Institutes of Health

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