The theory of modulated hormone therapy for the treatment of breast cancer in pre- and post-menopausal women
Source abstract
Abstract
We present a theory that questions the standard of care for pre- and post-menopausal women with breast cancer. Through the use of modulated hormones to mimic the natural multiphasic fluctuations of estrogen and progesterone cycles of healthy young women, it can be expected that patients will not only exhibit increased quality of life such as better sleep, well-being, and libido, but also memory improvement and less joint pain. Additionally, this regimen may engage genetic pathways that protect women in youth from breast cancers. We present a mathematical basis for the coupling of the hormone cycles through the use of Gaussian curves that provides the foundation of a new format of hormone replacement in women.
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Research context
OpenAlex topics: Estrogen and related hormone effects · Menopause: Health Impacts and Treatments · Cancer Risks and Factors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Wiley Systems 1 , Santa Fe, New Mexico 87505, USA
Los Alamos National Laboratory 2 Theoretical Division, , Los Alamos, New Mexico 87545, USA
Los Alamos National Laboratory 3 Center for Integrated Nanotechnologies, , Los Alamos, New Mexico 87545, USA
Funding
U.S. Department of Energy
References (41)
Show source-provided references
1. Journal of Evaluation in Clinical Practice · 2005 · 11 · 2110.1111/j.1365-2753.2004.00487.x ↗
2. Health and Quality of Life Outcomes · 2003 · 1 · 4510.1186/1477-7525-1-45 ↗
3. The Journal of the American Medical Association · 1992 · 267 · 94110.1001/jama.1992.03480070057030 ↗
4. Cancer · 1950 · 3 · 41010.1002/1097-0142(1950)3:3<410::AID-CNCR2820030303>3.0.CO;2-H ↗
5. Cancer Research · 1978 · 38 · 4021
6. PLoS ONE · 2009 · 4 · e769510.1371/journal.pone.0007695 ↗
7. International Journal of Cancer · 2008 · 123 · 93310.1002/ijc.23655 ↗
8. Journal of Endocrinology · 2003 · 178 · 31910.1677/joe.0.1780319 ↗
9. European Molecular Biology Organization Journal · 1990 · 9 · 160310.1002/j.1460-2075.1990.tb08280.x ↗
10. Endocrine Reviews · 1997 · 18 · 50210.1210/er.18.4.502 ↗
11. Molecular and Cellular Biology · 1994 · 14 · 8356
12. 1956
13. The New England Journal of Medicine · 2009 · 360 · 57310.1056/NEJMoa0807684 ↗
14. Journal of the National Cancer Institute · 2005 · 97 · 126710.1093/jnci/dji250 ↗
15. Lancet Oncol. · 2010 · 11 · 113510.1016/S1470-2045(10)70257-6 ↗
16. Journal of Clinical Oncology · 2011 · 29 · 416010.1200/JCO.2010.32.9615 ↗
17. The Journal of the American Medical Association · 2000 · 283 · 48510.1001/jama.283.4.485 ↗
18. Writing Group for the Women's Health Initiative Investigator · The Journal of the American Medical Association · 2002 · 288 · 32110.1001/jama.288.3.321 ↗
19. Journal of Steroid Biochemistry and Molecular Biology · 2000 · 74 · 27910.1016/S0960-0760(00)00104-7 ↗
20. J. Biol. Chem. · 2003 · 278 · 691210.1074/jbc.M208501200 ↗
21. The Journal of Pharmacology and Experimental Therapeutics · 2000 · 295 · 43110.1016/S0022-3565(24)38923-2 ↗
22. Journal of the National Cancer Institute · 1998 · 90 · 160110.1093/jnci/90.21.1601 ↗
23. Clinical Cancer Research · 2003 · 9 · 280s
24. American Journal of Obstetrics and Gynecology · 1993 · 168 · 82410.1016/S0002-9378(12)90828-5 ↗
25. Breast Cancer Research · 2002 · 4 · 13310.1186/bcr436 ↗
26. Molecular Cell Biology · 1999 · 202 · 5310.1023/A:1007081021483 ↗
27. Clinical Cancer Research · 2000 · 6 · 4653
28. Molecular Endocrinology · 2010 · 21 · 439
29. The Oncologist · 2006 · 11 · 43510.1634/theoncologist.11-5-435 ↗
30. The Journal of Clinical Endocrinology and Metabolism · 1999 · 84 · 187510.1210/jc.84.6.1875 ↗
31. Molecular and Cellular Endocrinology · 2001 · 172 · 3110.1016/S0303-7207(00)00397-X ↗
32. Cancer Prevention Research · 2011 · 10 · 1158
33. Modern Pathology · 2002 · 12 · 134810.1097/01.MP.0000039566.20817.46 ↗
34. Molecular and Cellular Endocrinology · 2001 · 17910.1016/S0303-7207(01)00465-8 ↗
35. The Journal of Biological Chemistry · 1992 · 267 · 1088210.1016/S0021-9258(19)50100-4 ↗
36. American Journal of Epidemiology · 1990 · 131 · 96110.1093/oxfordjournals.aje.a115616 ↗
37. Annals of New York Academy of Sciences · 2003 · 1010 · 32110.1196/annals.1299.057 ↗
38. Pharmacological Reviews · 2000 · 52 · 51310.1016/S0031-6997(24)01468-6 ↗
39. European Journal of Pharmacology · 2008 · 583 · 25510.1016/j.ejphar.2007.11.073 ↗
40. Journal of Clinical Endocrinology and Metabolism · 1996 · 81 · 409510.1210/jc.81.11.4095 ↗
41. Molecular Cancer · 2002 · 1 · 118610.1186/1476-4598-1-7 ↗