journal article·2012-09-01Open access

Robust and economical multi-sample, multi-wavelength UV/vis absorption and fluorescence detector for biological and chemical contamination

Peter J. Lu, Melanie M. Hoehl, James B. Macarthur, Peter A. Sims, Hongshen Ma, Alexander H. Slocum

AIP Advances· Volume 2· Issue 3

Abstract

We present a portable multi-channel, multi-sample UV/vis absorption and fluorescence detection device, which has no moving parts, can operate wirelessly and on batteries, interfaces with smart mobile phones or tablets, and has the sensitivity of commercial instruments costing an order of magnitude more. We use UV absorption to measure the concentration of ethylene glycol in water solutions at all levels above those deemed unsafe by the United States Food and Drug Administration; in addition we use fluorescence to measure the concentration of d-glucose. Both wavelengths can be used concurrently to increase measurement robustness and increase detection sensitivity. Our small robust economical device can be deployed in the absence of laboratory infrastructure, and therefore may find applications immediately following natural disasters, and in more general deployment for much broader-based testing of food, agricultural and household products to prevent outbreaks of poisoning and disease.
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Research context

OpenAlex topics: Biosensors and Analytical Detection · Analytical Chemistry and Sensors · Advanced Chemical Sensor Technologies

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Affiliations

Harvard-MIT Division of Health Sciences Technology 2 , Cambridge MA 02139 USA

Department of Mechanical Engineering 3 , MIT, Cambridge MA 02139 USA

Harvard University 1 Department of Physics and SEAS, , Cambridge, Massachusetts 02138, USA

Columbia University Medical Center 4 Department of Biochemistry and Molecular Biophysics, , New York, New York, 10032, USA

Columbia University Medical Center 5 Columbia Initiative in Systems Biology, , New York, New York, 10032, USA

University of British Columbia 6 Department of Mechanical Engineering, , Vancouver, British Columbia, Canada V6T 1Z4

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