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journal article·2024-03-01Open access

In vitro degradation behavior of oriented microcellular poly(L-lactic acid) biomimetic materials

Zhengqiu Li, Yueling Chen, Wenchao Yang, Jingbiao Ye, Xiangqian Song, Ying Jin, Xiaoqing Liu

AIP Advances· Volume 14· Issue 3
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Source abstract

Abstract

This paper investigated the static in vitro degradation behavior of poly(L-lactic acid) (PLLA)-oriented microcellular materials. The study compared the influence of different molecular chains and internal morphological structures on water penetration into the material. Also, the relationship between thse self-accelerated degradation caused by ester bond breakage and reduced material molecular weight and mechanical properties was explored. Furthermore, the mechanism behind the static in vitro degradation of oriented microcellular PLLA materials in simulated human body fluid was explored, laying the foundation for regulating the mechanical performance decline of oriented microcellular biomimetic bone repair materials to match specific bone healing periods.
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Research context

OpenAlex topics: biodegradable polymer synthesis and properties · Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Polymer and Composite Materials Division, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Zhejiang Provincial Key Laboratory of Bio-based Polymer Materials Technology and Application 1 , Ningbo 315201, Zhejiang, China

Hengdian Group TOSPO Engineering Plastics, Co., Ltd. 2 , Dongyang 322100, Zhejiang, China

School of Material Science and Engineering of Xihua University 3 , Chengdu 610039, Sichuan, China

Funding

Science and Technology Department of Sichuan Province · Science and Technology Department of Zhejiang Province · Science and Technology Department of Liangshan · National Natural Science Foundation of China · Chunhui Project Foundation of the Education Department of China · Xihua University

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