DataVXAIP AdvancesPaper
journal article·2018-02-01Open access

Accurate real-time sensing tip for aqueous NO with optical fibers embedded in active hydrogel waveguide

Chieh-Wen Chung, May-Jywan Tsai, Peng-Wei Lin, Ding-Wen Huang, Kuan-Hsun Wang, Yu-An Chen, Hsin-Fei Meng, Hsiao-Wen Zan, Henrich Cheng, Limin Tong, Lei Zhang, Sheng-Fu Horng, Cheng-Hsiung Hung

AIP Advances· Volume 8· Issue 2
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Source abstract

Abstract

A NO sensing tip is made by inserting two parallel optical fibers inside a poly 2-hydroxyethyl methacrylate (PolyHEMA) hydrogel waveguide mixed with the probe molecule 1, 2-Diaminoanthraquinone (DAQ). There is a length difference of 1 mm between the two fibers, and the light has to propagate through the difference from the short fiber to the long fiber. The total cross section area of the active hydrogel waveguide embedded with the fibers is only 3mm x 1.2 mm. For practical use the tip is housed in a needle for mechanical protection and the sensing tip is able to detect aqueous NO concentration around 1 μM with time resolution about 5 minutes. Such a sensing tip can be used to monitor the medical conditions inside the brain after a stroke or a brain injury.
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Research context

Polymers

OpenAlex topics: Analytical Chemistry and Sensors · Advanced Chemical Sensor Technologies · Electrochemical sensors and biosensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Photonics and the Institute of Electro-Optical Engineering, National Chiao Tung University 2 , Hsinchu 300, Taiwan, Republic of China

Department of Neurosurgery, Taipei Veterans General Hospital 5 , Taipei 112, Taiwan, Republic of China

Institute of Biomedical Engineering, National Chiao Tung University 4 , Hsinchu 300, Taiwan, Republic of China

Institute of Physics, National Chiao Tung University 1 , Hsinchu 300, Taiwan, Republic of China

State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University 6 , Hangzhou 310027, China

Institute of Electronic Engineering, National Tsing Hua University 3 , Hsinchu 300, Taiwan, Republic of China

Institute of Chemistry, Academia Sinica 7 , Taipei 115, Taiwan, Republic of China

Funding

Veterans General Hospitals and University Systems of Taiwan Joint Research Program · Ministry of Science and Technology, Taiwan

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