Recent advances in immunotherapy-involved combination cancer therapy based on ZIF-8

This paper introduces and briefly describes the tumor immune cycle to clarify the action mechanisms and principles of classical immunotherapy. We then focus on the classification of immunotherapies. Immunotherapy strategies can be classified into three categories according to the target of action: immunotherapy based on the regulation of dendritic cells, immunotherapy based on polarized tumor-associated macrophages, and immunotherapy based on the suppression of regulatory T cells. Subsequently, the latest research progress in the use of Zeolitic Imidazolate Framework-8 (ZIF-8) as a vehicle to combine immunotherapy with other therapeutic approaches is examined. Finally, prospects for the application of nanocomposites in combination therapy for tumor immunotherapy are outlined.