journal article·2022-03-01Open access

Optoacoustic imaging with an air-coupled transducer using coaxially aligned focused illumination

Cagla Özsoy, Jianuo Xu, Jiao Li, Francisco Montero de Espinosa, Daniel Razansky, Xosé Luís Deán-Ben

AIP Advances· Volume 12· Issue 3

Abstract

Optoacoustic (OA) methods have become powerful tools in biomedical research capable of retrieving functional information from biological tissues in vivo. Acquisition of OA signals generally relies on direct physical contact of a transducer or an acoustic coupling medium with the tissue surface, which prevents applicability, e.g., in open surgeries or wounded tissues. Non-contact OA imaging has been achieved with air-coupled piezoelectric transducers, which provide a straightforward approach for remote sensing of ultrasound vibrations. However, sensitivity was hampered by a suboptimal alignment between the illumination and detection fields. Herein, we devised an air-coupled transducer featuring a central aperture for light delivery with coaxially aligned optical and acoustic foci, thus providing optimal sensitivity for OA signal detection. Imaging of phantoms and a mouse ear in vivo is showcased by raster-scanning the transducer with light being delivered through a multimode optical fiber.
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Research context

OpenAlex topics: Photoacoustic and Ultrasonic Imaging · Optical Coherence Tomography Applications · Optical Imaging and Spectroscopy Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich 1 , 8057 Zürich, Switzerland

Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich 2 , 8093 Zürich, Switzerland

School of Precision Instruments and Optoelectronics Engineering, Tianjin University 3 , Tianjin 300072, China

Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin University 4 , Tianjin 300072, China

CSIC, Institute of Physics and Communication Technologies 5 , Madrid, Spain

Funding

Helmut Horten Stiftung · National Natural Science Foundation of China-Guangdong Joint Fund · Tianjin Municipal Government of China · Spanish Universities Ministery · H2020 European Research Council

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