Functional improvement in β cell models of type 2 diabetes using on-demand feedback control
Source abstract
Abstract
The bursting activity of pancreatic β cells is correlated with insulin secretion. Although normal pancreatic β cells show periodic bursting, the bursting activity becomes irregular in dysfunctional pancreatic β cells of type 2 diabetic patients. In this study, we modeled the dynamics of dysfunctional pancreatic β cells using differential equations. We investigated it in terms of energy efficiency of control. The control method is considered for on-demand electrical stimulation using the methodology of chaos control. Numerical simulation results show that the bursts are controlled in a periodic rhythm by the feedback mechanism. In addition, we found input timings that induce energy efficient control for rhythmic bursts. These results suggest that chaos control can improve insulin secretion, which might contribute to type 2 diabetes treatment.
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Research context
OpenAlex topics: Pancreatic function and diabetes · stochastic dynamics and bifurcation · Gene Regulatory Network Analysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Graduate School of Systems and Information Engineering, University of Tsukuba 1-1-1 Tennoudai, Tsukuba 1 , Ibaraki 305-8577, Japan
Advanced Institute for Materials Research, Tohoku University 2-1-1 Katahira, Aoba-ku 2 , Sendai 980-8577, Japan
International Research Center for Neurointelligence, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku 3 , Tokyo 113-0033, Japan
Funding
Japan Society for the Promotion of Science · Japan Agency for Medical Research and Development · Core Research for Evolutional Science and Technology · Moonshot Research and Development Program
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