Development of an open hardware bioreactor for optimized cardiac cell culture integrating programmable mechanical and electrical stimulations
Source abstract
Abstract
A new open-hardware bioreactor capable of applying electrical field stimulation in conjunction with static or cyclic stretch is presented. Stretch is applied to cells by a specially designed elastomeric membrane with a central seeding region. The main interest of our approach is the fine control of the characteristics of stimulations in regard to timing and amplitude in a simple design based on affordable, easy to find components and 3D printable parts. Our approach opens the way to more complex protocols for electrical and/or mechanical stimulations, which are known important regulators of cardiac phenotypes.
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Research context
OpenAlex topics: Tissue Engineering and Regenerative Medicine · Electrospun Nanofibers in Biomedical Applications · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Research Center, Montreal Heart Institute 1 , Montreal, Quebec H1T 1C8, Canada
Department of Pharmacology and Physiology, Université de Montréal 2 , Montreal, Quebec H3T 1J4, Canada
Institute of Biomedical Engineering, Université de Montréal 3 , Montreal, Quebec H3T 1J4, Canada
Department of Physiology, University of Bern 4 , CH-3012 Bern, Switzerland
Department of Medinine, Universite de Montreal 5 , Quebec, Canada
Funding
Natural Sciences and Engineering Research Council of Canada · Fondation Institut de Cardiologie de Montréal
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