journal article·2015-08-01Open access

Ionic charge transport between blockages: Sodium cation conduction in freshly excised bulk brain tissue

David Emin, Massoud Akhtari, B. M. Ellingson, G. W. Mathern

AIP Advances· Volume 5· Issue 8

Abstract

We analyze the transient-dc and frequency-dependent electrical conductivities between blocking electrodes. We extend this analysis to measurements of ions’ transport in freshly excised bulk samples of human brain tissue whose complex cellular structure produces blockages. The associated ionic charge-carrier density and diffusivity are consistent with local values for sodium cations determined non-invasively in brain tissue by MRI (NMR) and diffusion-MRI (spin-echo NMR). The characteristic separation between blockages, about 450 microns, is very much shorter than that found for sodium-doped gel proxies for brain tissue, >1 cm.
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Research context

OpenAlex topics: Advanced MRI Techniques and Applications · Neuroscience and Neural Engineering · Neuroscience and Neuropharmacology Research

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Affiliations

University of New Mexico 1 Department of Physics and Astronomy, , Albuquerque, NM 87131, USA

University of California at Los Angeles 2 Semple Institutes for Neuroscience and Human Behavior, David Geffen School of Medicine, , Los Angeles, CA 90095, USA

University of California at Los Angeles 3 Department of Radiology, David Geffen School of Medicine, , Los Angeles, CA 90095, USA

University of California at Los Angeles 4 Department of Neurosurgery, David Geffen School of Medicine, , Los Angeles, CA 90095, USA

Funding

UCLA Semel Institute for Neuroscience and Human Behavior · National Institutes of Health

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