Antibacterial activity of Ag+/MAF-7 nanocomposites against Enterococcus faecalis
Source abstract
Abstract
Enterococcus faecalis (E. faecalis) is one of the dominant bacteria in infected root canals, and it is tolerant to commonly used root canal disinfectants. Ag+ has a certain antibacterial effect on E. faecalis, but the instability and potential toxicity of Ag+ limit its application. Metal azolate framework-7 (MAF-7) is a typical metal–organic framework that has been used for drug delivery due to its high encapsulation efficiency, tunable release profile, and low cytotoxicity. In this study, we used a simple method for the synthesis of Ag+/MAF-7 nanocomposites. After characterization via several techniques, the antibacterial activity of this nanocomposite against E. faecalis was investigated. Ag+ was found to be uniformly bound to MAF-7, and the resulting Ag+/MAF-7 nanocomposite showed significant antibacterial activity against E. faecalis. This study demonstrates the potential application of nanocomposite antibacterial materials in treating infected root canals.
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Research context
OpenAlex topics: Magnesium Oxide Properties and Applications · Bone Tissue Engineering Materials · Facial Trauma and Fracture Management
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Dentistry, Stomatological Hospital, Tianjin Medical University 1 , Tianjin 300070,
Tianjin Stomatological Hospital, School of Medicine, Nankai University 2 , Tianjin 300041,
Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction 3 , Tianjin 300041,
School of Materials Science and Engineering, Nankai University 4 , Tianjin 300071,
Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration 5 , Tianjin 300070,
Funding
The General Project of Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction · the Tianjin Key Medical Discipline (Specialty) Construction Project
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