GSH-responsive magnetic mesoporous silica nanoparticles for efficient controlled drug delivery in tumor cells
Source abstract
Abstract
In this study, glutathione (GSH)-responsive magnetic mesoporous silica nanoparticles grafted by disulfide organosilicon (SMNPs) were synthesized, characterized, and evaluated as controlled drug carriers. The nanoparticles exhibited consistent dispersion, considerable drug-loading capacity, and high saturation magnetization. Importantly, they demonstrated the ability to release doxorubicin (DOX) by up to 43% in a reducing tumor microenvironment, highlighting their potential for targeted therapy. In addition, the SMNPs displayed favorable biocompatibility, making them suitable for biomedical applications. Most notably, the SMNPs loaded with DOX effectively killed both HepG2 and HeLa cancer cells, while also showing efficient cellular uptake in HeLa cells. These findings suggest that SMNPs are a promising platform for magnetic-targeted and GSH-responsive delivery of therapeutic agents.
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Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Graphene and Nanomaterials Applications · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Basic Medical Sciences, Shanxi Medical University 1 , Taiyuan 030001,
Department of Oncology, The Second Hospital of Shanxi Medical University 2 , Taiyuan 030001,
Funding
Natural Science Foundation of Shanxi Province · Shanxi Province Higher education “Billion Project” Science and Technology Guidance Project · Shanxi Scholarship Council of China · PhD Start-up Foundation of Shanxi Medical University · Shanxi Graduate Research Innovation Project
References (38)
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