Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles

Ryuichi Hirota; Toru Murayama; Ryota Katsumi; Tokuhisa Kawawaki; Shin Yabukami; Ryuji Igarashi; Yuichi Negishi; Moriaki Kusakabe; Masaki Sekino; Takashi Yatsui; Akihiro Kuwahata

doi:10.1063/9.0000483

journal article·2023-02-01Open access

Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles

Ryuichi Hirota, Toru Murayama, Ryota Katsumi, Tokuhisa Kawawaki, Shin Yabukami, Ryuji Igarashi, Yuichi Negishi, Moriaki Kusakabe, Masaki Sekino, Takashi Yatsui, Akihiro Kuwahata

AIP Advances· Volume 13· Issue 2

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Source abstract

Abstract

Virus detection methods based on nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic are widely applied, owing to their high sensitivity and short measurement time. This paper proposes a virus detection method based on the second harmonic because of its larger signal component. We found that the second harmonic signal is superior to the third harmonic signal for small nanobeads and a large change of the second harmonic signal in the signal-to-noise ratio (SNR) with nanobeads concentration. In addition, a virus detection limit of 100 pg/ml is achieved. Therefore, the proposed method can potentially be utilized for rapid screening of viruses.

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Research context

Nanomaterials

OpenAlex topics: Characterization and Applications of Magnetic Nanoparticles · Biosensors and Analytical Detection · Microfluidic and Bio-sensing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Graduate School of Engineering, Tohoku University 1 , Sendai, Miyagi 980-8579, Japan

Graduate School of Engineering, Toyohashi University of Technology 2 , Toyohashi, Aichi 441-8580, Japan

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science 3 , Tokyo 162-8601, Japan

Faculty of Engineering, Tohoku Gakuin University 4 , Sendai, Miyagi 985-8537, Japan

Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology 5 , Chiba 263-8555, Japan

Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo 6 , Tokyo 113-8657, Japan

Matrix Cell Research Institute Inc. 7 , Ibaraki 300-1232, Japan

Graduate School of Engineering, The University of Tokyo 8 , Tokyo 113-8656, Japan

Funding

Uehara Memorial Foundation · Hitachi Global Foundation · Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering · Adaptable and Seamless Technology Transfer Program Through Target-Driven R and D · Japan Agency for Medical Research and Development · High Energy Accelerator Research Organization

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