Thermal and pH responsive ZnO-based nanoparticles for efficient drug delivery
Source abstract
Abstract
In this paper, we reported a ZnO quantum dot (QD) based nano drug delivery system by surface modification of hydrophilic copolymer poly(methacrylate-co-N-isopropylacrylamide-co-polyethylene glycol methyl acrylate) (ZnO@PMNE) that was synthesized by the one step copolymerization method. The ZnO@PMNE nanoparticles (ZnO@PMNE NPs) have excellent stability and photoluminescence performance in water. Moreover, it is temperature responsive and biodegradable in an acid microenvironment. ZnO@PMNE NPs loaded with doxorubicin (DOX) will degrade to zinc ions (Zn2+) and DOX at an acidic tumor microenvironment. Moreover, the cytotoxicity of cancer cells was significantly increased because the ZnO QDs exhibited cytotoxicity postdissolution compared to normal cells, which will achieve a synergistic antitumor effect to improve the therapeutic index.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Quantum Dots Synthesis And Properties · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences 1 , Suzhou 215163, China
Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University 2 , Qingdao 266071, China
University of Science and Technology of China 3 , Hefei 230026, China
Tianjin Guokeyigong Science and Technology Development Co., Ltd. 4 , Tianjin 300399, People’s Republic of China
Funding
Chinese Academy of Sciences Progrma · The Nation Key Research and Development Program of Tianjin
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