Adsorption of 5-Fluorouracil on Au(111) and Cu(111) surfaces
Source abstract
Abstract
The adsorption of 5-Fluorouracil (5FU) on Au(111) and Cu(111) surfaces as a function of molecular coverage and temperature has been studied, using x-ray photoelectron spectroscopy (XPS) and near-edge x-ray absorption fine structure (NEXAFS) spectroscopy. The nature of 5-Fluorouracil bonding with the two substrates is remarkably different. The Cu substrate forms a chemisorbed complex with 5-FU while the Au substrate shows only physisorption. NEXAFS data at the C, N and O K-edge show a strong angular dependence, indicating that 5-FU lies nearly parallel on the inert Au(111) surface, and at a steep angle on the Cu(111) surface. 5-FU is a biomolecule used for cancer treatment and the results are relevant for those using metal surfaces to prepare 5-FU for applications such as drug delivery.
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Research context
OpenAlex topics: Molecular Junctions and Nanostructures · Surface and Thin Film Phenomena · Surface Chemistry and Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Aarhus University, Department of Physics and Astronomy 1 , Ny Munkegade 120, DK-8000 Aarhus C, Denmark
Charles University, Faculty of Mathematics and Physics, Department of Surface and Plasma Science 2 , V Holešovičkách 2, 18000 Prague 8, Czech Republic
Peter Grünberg Institute (PGI-6) and JARA-FIT, Research Center Jülich 3 , 52425 Jülich, Germany
Sincrotrone Trieste S.C.p.A. 4 , in Area Science Park, Strada Statale 14, km 163.5, I-34149 Basovizza, Trieste, Italy
I.O.M.-C.N.R. 5 , in Area Science Park, Strada Statale 14, km 163.5, I-34149 Basovizza, Trieste, Italy
Funding
CERIC-ERIC · Czech Ministry of Education
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