Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays
Source abstract
Abstract
Effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.
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Research context
OpenAlex topics: Mechanical and Optical Resonators · Advanced MEMS and NEMS Technologies · Force Microscopy Techniques and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Oak Ridge National Laboratory 1 , Oak Ridge, TN 37831, USA
Clinical Investigations Facility 2 , David Grant USAF Medical Center, Travis Air Force Base, CA 94535-1809, USA
University of Alberta 3 Department of Chemical and Materials Engineering, , Edmonton, Alberta, T6G 2V4, Canada
University of Tennessee 4 Department of Physics, , Knoxville, TN 37996, USA
University of Tennessee 5 Department of Chemical and Biomolecular Engineering, , Knoxville, TN 37996-2200, USA
Funding
DOE
References (13)
Show source-provided references
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