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journal article·2017-08-01Open access

Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation

J. Jain, J. Moreno, R. Andaur, R. Armisen, D. Morales, K. Marcelain, G. Avaria, B. Bora, S. Davis, C. Pavez, L. Soto

AIP Advances· Volume 7· Issue 8
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Source abstract

Abstract

Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely “PF-400J”, was adapted to irradiate colorectal cancer cell line, DLD-1. For pulsed x-rays, the doses (energy absorbed per unit mass, measured in Gy) were measured using thermoluminescence detectors (TLD-100 dosimeters). The neutron fluence and the average energy were used to estimate the pulsed neutron doses. Fifty pulses of x-rays (0.12 Gy) and fifty pulses of neutrons (3.5 μGy) were used to irradiate the cancer cells. Irradiation-induced DNA damage and cell death were assessed at different time points after irradiation. Cell death was observed using pulsed neutron irradiation, at ultralow doses. Our results indicate that the PF-400J can be used for in vitro assessment of the effect of pulsed radiation in cancer cell research.
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Research context

OpenAlex topics: Laser-Plasma Interactions and Diagnostics · Nuclear Physics and Applications · Ion-surface interactions and analysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Universidad de Talca 1 , 2 Norte 685, Casilla 721, Talca, Chile

Comisión Chilena de Energía Nuclear 2 , Casilla 188-D, Santiago, Chile

Center for Research and Applications in Plasma Physics and Pulsed Power 3 , Santiago 7600713, Santiago, Chile

Universidad Andres Bello, Departamento de Ciencias Fisicas 6 , Republica 220, Santiago, Chile

Departamento de Oncología Básico-clínica, Facultad de Medicina, Universidad de Chile 4 , Independencia 1027, Independencia, Santiago, Chile

Centro de Investigación y Tratamiento del Cáncer, Facultad de Medicina, Universidad de Chile 5 , Independencia 1027, Independencia, Santiago, Chile

Current affiliation: Center for Excellence in Precision Medicine, Pfizer Chile 7 , Santiago 7810305, Santiago, Chile

Funding

CONICYT-PIA

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