journal article·2025-04-01Open access

A novel self-attentive deep learning for predicting pregnancy outcome after hysteroscopic adhesiolysis in patients with intrauterine adhesions

Yueqi Li, Jieying Zheng, Yong Shi, Jiansheng Wu, Danhong Peng, Jun Wang

AIP Advances· Volume 15· Issue 4

Abstract

This study presents SDL-IUAs, a novel deep learning framework that employs a self-attention mechanism to predict pregnancy outcomes in patients with intrauterine adhesions (IUAs) following hysteroscopic adhesiolysis. By integrating random forest-based feature importance analysis with self-attention, the model achieves enhanced predictive accuracy and interpretability. The experiments were conducted on a clinical dataset of 121 patients with 163 features, where 16.05% missing values were effectively handled using a matrix decomposition approach. SDL-IUAs demonstrated superior performance compared to traditional models, attaining an AUC of 0.96, a precision of 0.95, a recall of 0.94, and an F1-score of 0.94. Feature importance analysis highlighted age as a key predictive factor, providing actionable insights for clinical decision-making and personalized treatment planning. These results underscore the potential of SDL-IUAs as a robust, interpretable, and clinically applicable tool for pregnancy outcome prediction in IUA patients. The methodological advancements introduced in this study are expected to catalyze further research and innovation in this domain, ultimately contributing to improved clinical outcomes for IUA patients.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Gynecological conditions and treatments · Uterine Myomas and Treatments · Ectopic Pregnancy Diagnosis and Management

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Faculty of Cosmic Research, Lomonosov Moscow State University 1 , Moscow 119234,

School of Communications and Information Engineering, Nanjing University of Posts and Telecommunications 2 , Nanjing 210023,

Department of Obstetrics and Gynecology, Zhongda Hospital of Southeast University 3 , Nanjing 210009,

School of Computer Science, Nanjing University of Posts and Telecommunications 4 , Nanjing 210023,

Smart Health Big Data Analysis and Location Services Engineering Research Center of Jiangsu Province, Nanjing University of Posts and Telecommunications 5 , Nanjing 210023,

Funding

National Natural Science Foundation of China · Shandong Key Laboratory of Biophysics · Basic Research Program of Science and Technology Department of Jiangsu Province

References (28)

Show source-provided references
1. Hysteroscopic removal of retained products of conception implanted over a focal area of adenomyosis: A case report10.1016/j.jmig.2017.09.010 ↗
2. Incidence of intrauterine adhesions after hysteroscopic myomectomy in patients seeking fertility10.1016/j.jmig.2023.05.013 ↗
3. Office operative hysteroscopy: An update10.1016/j.jmig.2017.08.009 ↗
4. Hysteroscopic dilation techniques in hysteroscopic adhesiolysis10.11817/j.issn.1672-7347.2022.220059 ↗
5. Creation of a rabbit model for intrauterine adhesions using electrothermal injury10.1631/jzus.b1700086 ↗
6. Therapeutic options and drug delivery strategies for the prevention of intrauterine adhesions10.1016/j.jconrel.2019.12.007 ↗
7. Decision tree model predicts live birth after surgery for moderate-to-severe intrauterine adhesions10.1186/s12884-022-04375-x ↗
8. Reproductive outcomes after surgical treatment of Asherman syndrome: A systematic review10.1016/j.bpobgyn.2018.12.009 ↗
9. Postoperative reproductive results of infertile patients with intrauterine adhesions: A retrospective analysis10.1177/03000605221119664 ↗
10. Live birth rate and obstetric complications following the hysteroscopic management of intrauterine adhesions including Asherman syndrome10.1093/humrep/dey237 ↗
11. Relationship between endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound and pregnancy after intrauterine insemination10.1016/j.fertnstert.2009.03.084 ↗
12. Detection of endometrial and subendometrial vasculature on the day of embryo transfer and prediction of pregnancy during fresh in vitro fertilization cycles10.1016/j.tjog.2013.05.007 ↗
13. Serial uterine artery Doppler velocity parameters and human uterine receptivity in IVF/ICSI cycles10.1002/uog.5179 ↗
14. Localization of angiogenic growth factors and their receptors in the human endometrium throughout the menstrual cycle and in recurrent miscarriage10.1093/humrep/der376 ↗
15. Doppler assessment of uterine artery blood flow for the prediction of pregnancy after assisted reproduction treatment10.1002/uog.5321 ↗
16. Logistic regression analyses of factors affecting fertility of intrauterine adhesions patients10.21037/atm.2019.11.115 ↗
17. Clinical application of three-dimensional transvaginal ultrasonography in the diagnosis of intrauterine adhesions10.1177/03000605211024520 ↗
18. Machine learning and decision support in critical care10.1109/jproc.2015.2501978 ↗
19. An XGBoost predictive model of ongoing pregnancy in patients following hysteroscopic adhesiolysis10.1016/j.rbmo.2023.01.019 ↗
20. Factors affecting pregnancy outcomes following the surgical removal of intrauterine adhesions and subsequent in vitro fertilization and embryo transfer10.3892/etm.2019.7935 ↗
21. Decision tree analysis: A retrospective analysis of postoperative recurrence of adhesions in patients with moderate-to-severe intrauterine10.1155/2019/7391965 ↗
22. The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, Müllerian anomalies and intrauterine adhesions10.1016/S0015-0282(16)59942-7 ↗
23. Large randomized trial comparing transabdominal ultrasound-guided embryo transfer with a technique based on uterine length measurement before embryo transfer10.1002/uog.15899 ↗
24. Pregnancy patterns impact live birth rate for patients with intrauterine adhesions after hysteroscopic adhesiolysis: A retrospective cohort study10.3389/fphys.2022.822845 ↗
25. Serum levels of anti-Müllerian hormone influence pregnancy outcomes associated with gonadotropin-releasing hormone antagonist treatment: A retrospective cohort study10.1038/s41598-023-28724-8 ↗
26. Placental pulsatility index: A new, more sensitive parameter for predicting adverse outcome in pregnancies suspected of fetal growth restriction10.1111/aogs.13060 ↗
27. The role of blood flow in corpus luteum measured by transvaginal two-dimensional and three-dimensional ultrasound in the prediction of early intrauterine pregnancy outcomes10.3389/fphar.2019.00767 ↗
28. Relationship of pre-ovulatory follicle size, estradiol concentrations and season to pregnancy outcome in dairy cows10.1016/j.anireprosci.2006.04.056 ↗