Wireless temperature monitoring by using magnetic nanoparticles for biomedical applications on magnetic hyperthermia treatment

Magnetic hyperthermia with magnetic nanoparticles (MNPs) has been introduced to selective treatment of tumor and the MNPs also has demonstrated diagnosis. For non-invasive treatment, a therapeutic platform with temperature monitoring that can avoid overheating in normal tissues is of vital importance. In this study, we have developed a wireless temperature monitoring system by utilizing the combination of magnetic harmonic signals of the MNPs for magnetic hyperthermia treatment in laboratory experiments. We achieved an accurate measurement with an error of 0.18 °C. For practical use on breast/oral cancer, a detectable distance of at least 10 mm is required. To demonstrate the feasibility toward future biomedical applications, we investigated the dependency on the amount of Resovist® and the error is less than 0.5 °C in a 10 mm distance. Our system can measure the correct temperature regardless of Resovist amount. The results indicate that our system can apply for monitoring temperature on magnetic hyperthermia treatment.