3D printed microfluidic chip integrated with nanointerferometer for multiplex detection of foodborne pathogens
Source abstract
Abstract
The current foodborne pathogen detection methods, such as culture-based methods, polymerase chain reaction, and optical and electrochemical biosensors with nucleic acid, have high sensitivity and selectivity. However, they are slow, expensive, and require well-trained operators. In this study, we utilized a 3D printer to develop a novel chip with an aptamer-based nanointerferometer capable of identifying four distinct foodborne pathogens: Listeria monocytogenes, Escherichia coli, Salmonella typhimurium, and Staphylococcus aureus. The aptamer sensor on the chip achieved a limit-of-detection of 10 colony forming unit (CFU)/ml. With its high sensitivity and specificity, this chip offers a cost-effective platform for distinguishing and screening different foodborne pathogens.
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Research context
OpenAlex topics: Biosensors and Analytical Detection · Advanced biosensing and bioanalysis techniques · Microfluidic and Bio-sensing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Integrated Circuits, Guangdong University of Technology 1 , Guangzhou 510006, China
Department of Orthopedics, Pudong New District People’s Hospital 2 , Shanghai, China
Funding
National Natural Science Foundation of China · Guangzhou Municipal Science and Technology Bureau · Shanghai Pudong New Area People’s Hospital Yuanhang Program Talent Training Project
References (45)
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