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journal article·2023-02-01Open access

Development of biocompatible Ni-ferrite nanoparticles with PEG-coated for magnetic hyperthermia

K. Ohara, T. Moriwaki, K. Nakazawa, T. Sakamoto, K. Nii, M. Abe, Y. Ichiyanagi

AIP Advances· Volume 13· Issue 2
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Source abstract

Abstract

In this study, NiFe2O4 nanoparticles were prepared as a thermophilic agent for magnetic thermotherapy. To improve biocompatibility, the particles were coated with polyethylene glycol, which is hydrophilic and nontoxic; X-ray diffraction measurements confirmed that the particle size could be controlled to 3, 6, 9, and 17 nm. Fourier-transform infrared spectroscopy confirmed PEG modification to the particles. Biocompatibility with cells were improved by coating with PEG of high molecular weight. The heat-generating effect of the particles was investigated by measuring the magnetic susceptibility and temperature rise in an AC magnetic field. Furthermore, a device using a zero-voltage switching circuit was developed to generate heat. Finally, in vitro experiments using human breast cancer cells were successfully performed to confirm the onset of the hyperthermia effect.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Microfluidic and Bio-sensing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physics, Graduate School of Engineering Science, Yokohama National University 1 , Yokohama, Kanagawa 240-8501, Japan

Department of National Environment, Graduate School of Environment and Information Science, Yokohama National University 2 , Yokohama, Kanagawa 240-8501, Japan

Graduate School of Engineering Science, Osaka University 3 , Toyonaka, Osaka 560-8531, Japan

Funding

Precursory Research for Embryonic Science and Technology · JST-Mirai Program · Japan Society for the Promotion of Science · Japan Agency for Medical Research and Development · Institute of Innovative Research, Tokyo Institute of Technology

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