Application of spectral-focusing-CARS microscopy to pharmaceutical sample analysis
Source abstract
Abstract
We implement spectral-focusing-CARS hyperspectroscopy to characterize pharmaceutical samples. The use of a dynamically-power-tuned supercontinuum seeding method combined with epi-detection of the CARS signals allows for broadband hyperspectroscopy and rapid single vibrational frequency imaging with microsecond pixel dwell times. The broad hyperspectral capabilities spanning about 3000 cm-1 of vibrational information allow for facile discrimination between ibuprofen, common polymorphs of acetaminophen, and starchy binders. Application of 3-D hyperspectral imaging on bare tablet forms reveals surface-bound processing of low-dose drugs such as cetirizine.
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Research context
OpenAlex topics: Spectroscopy Techniques in Biomedical and Chemical Research · Spectroscopy and Chemometric Analyses · Image Processing Techniques and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Physics and Astronomy, Trent University , Peterborough K9L 0G2, Canada
Funding
Canada Research Chairs · Natural Sciences and Engineering Research Council of Canada
References (41)
Show source-provided references
1. Scanning coherent anti-Stokes Raman microscope10.1364/ol.7.000350 ↗
2. Three-dimensional vibrational imaging by coherent anti-Stokes Raman scattering10.1103/physrevlett.82.4142 ↗
3. High-speed coherent Raman fingerprint imaging of biological tissues10.1038/nphoton.2014.145 ↗
4. Chemical imaging of oral solid dosage forms and changes upon dissolution using coherent anti-Stokes Raman scattering microscopy10.1021/ac8020856 ↗
5. In situ dissolution analysis using coherent anti-Stokes Raman scattering (CARS) and hyperspectral CARS microscopy10.1016/j.ejpb.2013.08.012 ↗
6. Imaging receptor-mediated endocytosis with a polymeric nanoparticle-based coherent anti-Stokes Raman scattering probe10.1021/jp073478z ↗
7. Label-free imaging of polymeric nanomedicines using coherent anti-Stokes Raman scattering microscopy10.1002/jrs.3170 ↗
8. Coherent anti-Stokes Raman scattering imaging of lipids in cancer metastasis10.1186/1471-2407-9-42 ↗
9. Stain-free histopathology by programmable supercontinuum pulses10.1038/nphoton.2016.94 ↗
10. Using Raman spectroscopy to characterize biological materials10.1038/nprot.2016.036 ↗
11. Comparing coherent and spontaneous Raman scattering under biological imaging conditions10.1364/ol.34.000773 ↗
12. Intrinsic indicator of photodamage during label-free multiphoton microscopy of cells and tissues10.1371/journal.pone.0110295 ↗
13. Intravital imaging study on photodamage produced by femtosecond near-infrared laser pulses in vivo10.1111/php.12572 ↗
14. Vibrational imaging with high sensitivity via epidetected coherent anti-Stokes Raman scattering microscopy10.1103/physrevlett.87.023901 ↗
15. Chemically sensitive bioimaging with coherent Raman scattering10.1038/nphoton.2015.60 ↗
16. An epi-detected coherent anti-Stokes Raman scattering (E-CARS) microscope with high spectral resolution and high sensitivity10.1021/jp003774a ↗
17. Molecular vibration imaging in the fingerprint region by use of coherent anti-Stokes Raman scattering microscopy with a collinear configuration10.1364/ol.25.001768 ↗
18. Multicomponent chemical imaging of pharmaceutical solid dosage forms with broadband CARS microscopy10.1021/ac400671p ↗
19. Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy10.1073/pnas.0508282102 ↗
20. Recent advances in nonlinear optical analyses of pharmaceutical materials in the solid state10.1021/acs.molpharmaceut.6b00809 ↗
21. Pharmaceutical applications of non-linear imaging10.1016/j.ijpharm.2010.12.017 ↗
22. Vibrational imaging of tablets by epi-detected stimulated Raman scattering microscopy10.1039/c0an00252f ↗
23. Spectral focusing: High spectral resolution spectroscopy with broad-bandwidth laser pulses10.1063/1.1768312 ↗
24. Coherent anti-Stokes Raman microspectroscopy using spectral focusing with glass dispersion10.1063/1.3028346 ↗
25. Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator10.1364/oe.17.002984 ↗
26. Resolution of spectral focusing in coherent Raman imaging10.1364/oe.26.010230 ↗
27. Interplay of pulse bandwidth and spectral resolution in spectral-focusing CARS microscopy10.1364/josab.35.000842 ↗
28. Brighter CARS hypermicroscopy via ‘spectral surfing’ of a Stokes supercontinuum10.1364/ol.42.002255 ↗
29. Spectrally-broad coherent anti-Stokes Raman scattering hyper-microscopy utilizing a Stokes supercontinuum pumped at 800 nm10.1364/boe.7.004335 ↗
30. Quantitative, comparable coherent anti-Stokes Raman scattering (CARS) spectroscopy: Correcting errors in phase retrieval10.1002/jrs.4824 ↗
31. 28 2018
32. Fiji: An open-source platform for biological-image analysis10.1038/nmeth.2019 ↗
33. Reference database of Raman spectra of pharmaceutical excipients10.1002/jrs.2125 ↗
34. Raman detected differential scanning calorimetry of polymorphic transformations in acetaminophen10.1016/j.jpba.2008.09.008 ↗
35. Quantitative analysis of paracetamol polymorphs in powder mixtures by FT-Raman spectroscopy and PLS regression10.1016/j.jpba.2006.07.032 ↗
36. Vibrational properties of ibuprofen-cyclodextrin inclusion complexes investigated by Raman scattering and numerical simulation10.1002/jrs.2150 ↗
37. Vibrational and theoretical studies of non-steroidal anti-inflammatory drugs Ibuprofen [2-(4-isobutylphenyl)propionic acid]; Naproxen [6-methoxy-α-methyl-2-naphthalene acetic acid] and Tolmetin acids [1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid]10.1016/j.molstruc.2005.08.018 ↗
38. Raman spectroscopy of racemic ibuprofen: Evidence of molecular disorder in phase II10.1016/j.ijpharm.2011.09.015 ↗
39. Raman spectroscopy as a process analytical technology tool for the understanding and the quantitative in-line monitoring of the homogenization process of a pharmaceutical suspension10.1039/b605299a ↗
40. Confocal Raman-spectroscopy: Analytical approach to solid dispersions and mapping of drugs10.1023/a:1018956304595 ↗
41. A new pure paracetamol for direct compression: The orthorhombic form10.1016/0378-5173(95)04127-3 ↗