Synthesis of multifunctional di-cationic ionic liquids: Unveiling antibacterial activity across diverse strains
Source abstract
Abstract
The increasing prevalence of antibiotic resistance poses a significant global risk to public health. Therefore, there is an urgent necessity to discover innovative antibacterial materials. In this study, we introduced a novel synthesis method that yielded 18 unique di-cationic ionic liquids (DILs), intricately crafted through a fusion of quaternization and metathesis reactions. These innovative compounds boasted imidazolium, pyridinium, and quaternary ammonium as their cationic constituents, accompanied by acetate and bisulfate ions as their anionic counterparts. The incorporation of spacer chains, specifically trans-1,4-dibromo-2-butene and α, α′-dibromo-p-xylene, facilitated the synthesis of these di-cations. Thorough characterization of the synthesized DILs was conducted using advanced spectroscopic techniques, including FTIR and nuclear magnetic resonance, ensuring a comprehensive understanding of their structural attributes. The central objective of this research was to assess the effectiveness of these DILs in combating a diverse spectrum of resilient bacterial strains commonly encountered in various environmental settings. This evaluation encompassed both gram-positive and gram-negative species.
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Research context
OpenAlex topics: Ionic liquids properties and applications · Multicomponent Synthesis of Heterocycles · Chemistry and Chemical Engineering
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, School of Natural Sciences (SNS), National University of Sciences and Technology (NUST) 1 , H-12, Islamabad 44000,
Depeartment of Chemical Engineering, Bogazici University 2 , 34342 Istanbul,
TUBITAK Marmara Research Center, Material Institute 3 , Gebze 41470,
Chemical Engineering Department, College of Engineering, King Saud University 4 , P.O. Box 800, Riyadh 1141,
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi 5 , Karachi 75270,
Department of Chemical Engineering Materials Environment, Sapienza University of Rome 6 , Rome,
Funding
Al-Amodi Autism Research Chair, King Saud University
References (36)
Show source-provided references
1. Antimicrobial ionic liquid-based materials for biomedical applications10.1002/adfm.202104148 ↗
2. Structure and properties of high stability geminal dicationic ionic liquids10.1021/ja046521u ↗
3. Phosphonium-ammonium-based di-cationic ionic liquids as antibacterial over the ESKAPE group10.1016/j.bmcl.2020.127389 ↗
4. Ionic liquid-based gels for biomedical applications10.1016/j.cej.2022.139248 ↗
5. Applications of ionic liquids in the chemical industry10.1039/b006677j ↗
6. Fabrication of ionic liquid based d-Ti3C2/MoO3 hybrid electrode system for efficient energy storage applications10.1016/j.electacta.2022.141036 ↗
7. Extraction of Am(iii) using novel solvent systems containing a tripodal diglycolamide ligand in room temperature ionic liquids: A ‘green’ approach for radioactive waste processing10.1039/c2ra20577g ↗
8. A novel CMPO-functionalized task specific ionic liquid: Synthesis, extraction and spectroscopic investigations of actinide and lanthanide complexes10.1039/c3dt32967d ↗
9. A diglycolamide-functionalized task specific ionic liquid (TSIL) for actinide extraction: Solvent extraction, thermodynamics and radiolytic stability studies10.1016/j.seppur.2013.07.005 ↗
10. An overview of molecular extractants in room temperature ionic liquids and task specific ionic liquids for the partitioning of actinides/lanthanides10.1007/s10967-020-07199-1 ↗
11. Comparison of the extraction and stripping behavior of iron (III) from weak acidic solution between ionic liquids and commercial extractants10.3365/kjmm.2019.57.12.787 ↗
12. Synthesis of succinimide based ionic liquids and comparison of extraction behavior of Co(II) and Ni(II) with bi-functional ionic liquids synthesized by Aliquat336 and organophosphorus acids10.1016/j.seppur.2019.116496 ↗
13. Highly efficient diglycolamide-based task-specific ionic liquids: Synthesis, unusual extraction behaviour, irradiation, and fluorescence studies10.1002/chem.201203321 ↗
14. Extraction of Pb (II) and Co (II) using N,N-dioctylsuccinamate based room temperature ionic liquids containing aliphatic and aromatic cations10.1016/j.arabjc.2022.104099 ↗
15. Diglycolamide based mono and di-ionic liquids having imidazolium cation for effective extraction and separation of Pb(II) and Co(II)10.1134/s0036023621070147 ↗
16. A comparative evaluation of antibacterial activities of imidazolium, pyridinium, and phosphonium based ionic liquids containing octyl side chains: Experimental and theoretical investigations10.1016/j.heliyon.2022.e09533 ↗
17. Synthesis, characterization, biological evaluation, and in silico studies of imidazolium-pyridinium-and ammonium-based ionic liquids containing n-butyl side chains10.3390/molecules27196650 ↗
18. Synthesis, evaluation, and in silico studies of imidazolium and pyridinium-based ionic liquids with Dioctyl succinamic acid anion for enhanced antibacterial applications10.1016/j.molliq.2024.124714 ↗
19. A review on dicationic ionic liquids: Classification and application10.4172/2169-0316.1000197 ↗
20. J. Chem. Eng. Data · 2011 · 56 · 245310.1021/je2000183 ↗
21. Dicationic imidazolium-based ionic liquids: A new strategy for non-toxic and antimicrobial materials10.1039/c4ra09906k ↗
22. A novel dicationic ionic liquids encompassing pyridinium hydrazone-phenoxy conjugates as antimicrobial agents targeting diverse high resistant microbial strains10.1016/j.molliq.2019.04.010 ↗
23. Quaternary ammonium compounds (QACs) and ionic liquids (ILs) as biocides: From simple antiseptics to tunable antimicrobials10.3390/ijms22136793 ↗
24. Ionic liquids: Emerging antimicrobial agents10.1007/s11095-022-03336-5 ↗
25. Synthesis of new water-soluble ionic liquids and their antibacterial profile against gram-positive and gram-negative bacteria10.1016/j.heliyon.2019.e02607 ↗
26. Synergistic antimicrobial activity of N-methyl substituted pyrrolidinium–based ionic liquids and melittin against Gram-positive and Gram-negative bacteria10.1007/s00253-020-10989-y ↗
27. Anionic structural effect in liquid–liquid separation of phenol from model oil by choline carboxylate ionic liquids10.1016/j.gee.2019.01.011 ↗
28. Amino acid-based dicationic ionic liquids as complex crop protection agents10.1016/j.molliq.2022.119357 ↗
29. 2023 · 40510.1016/B978-0-323-95931-5.00015-4 ↗
30. Long alkyl chain quaternary ammonium-based ionic liquids and potential applications10.1039/b604353d ↗
31. Investigating the effect of ionic liquid (1-dodecyl-3-methylimidazolium chloride ([c12mim])) on the water/oil interfacial tension as a novel surfactant10.1016/j.colsurfa.2012.12.008 ↗
32. A novel method for preparation of imidazolium tetrafluoroborate ionic liquids10.1016/j.jfluchem.2006.07.010 ↗
33. Dicationic imidazolium based ionic liquids: Synthesis and properties10.1016/j.molliq.2016.11.131 ↗
34. Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms10.1039/c5cc05159b ↗
35. Comparative evaluation of antimicrobial activity of different types of ionic liquids10.1016/j.msec.2019.109907 ↗
36. Synthesis, characterization and antimicrobial activities of dicationic triphenylphosphonium organic salts with a para xylene bridge and fluorinated counter anions