Production route analysis of a therapeutic radionuclide 177Lu
Source abstract
Abstract
177Lu is used in medical research for various radiotheragnostic applications in nuclear medicine because of its various isotope properties. In this paper, we calculated the cross sections and production yields of the Lu isotope from different reactions X+176,174Lu and X+176Lu in energy levels from 0.001 to 100 MeV by using TALYS-1.96 and EMPIRE-3.2.2. Although n, d, and t reactions show an outstanding cross-section performance, α and t reactions show very impactful integral yield data. For the potential outcomes, these estimates are analyzed by comparing them to TENDL-2019 and EMPIRE-3.2.2.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Radiopharmaceutical Chemistry and Applications · Nuclear physics research studies · Boron Compounds in Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Physics, University of Chittagong , Chattagram 4331, Bangladesh
References (22)
Show source-provided references
1. Production logistics of 177Lu for radionuclide therapy10.1016/s0969-8043(03)00158-1 ↗
2. Lutetium-177 therapeutic radiopharmaceuticals: Linking chemistry, radiochemistry, and practical applications10.1021/cr500171e ↗
3. Large-scale production of lutetium-177m for the 177mLu/177Lu radionuclide generator10.1016/j.apradiso.2019.108986 ↗
4. Production of 149Tb, 152Tb, 155Tb and 161Tb from gadolinium using different light-particle beams10.1007/s10967-019-06973-0 ↗
5. Production of 177Lu by neutron activation of 176Lu10.1007/s10967-004-0476-9 ↗
6. Production of lutetium-177: Process aspects10.1134/s1066362219040015 ↗
7. Production, quality control, biological evaluation and biodistribution modeling of Lutetium-177 maltolate as a viable bone pain palliative in skeletal metastasis10.1007/s10967-014-3603-2 ↗
8. Lutetium-labelled peptides for therapy of neuroendocrine tumours10.1007/s00259-011-2039-y ↗
9. Production of glass microspheres comprising 90Y and 177Lu for treating of hepatic tumors with SPECT imaging capabilities10.1016/j.apradiso.2011.05.026 ↗
10. Lutetium-177 DOTATATE production with an automated radiopharmaceutical synthesis system
11. Everolimus, lutetium-177 DOTATATE and sunitinib for advanced, unresectable or metastatic neuroendocrine tumours with disease progression: A systematic review and cost-effectiveness analysis10.3310/hta22490 ↗
12. Study of TOF-PET capability with Lutetium fine silicate and multi-pixel photon counter
13. Neuroendocrine tumor therapy with lutetium-177: A literature review10.7759/cureus.3986 ↗
14. Treatment with tandem [90Y]DOTA-TATE and [177Lu]DOTA-TATE of neuroendocrine tumours refractory to conventional therapy10.1007/s00259-013-2578-5 ↗
15. Production of no-carrier added lutetium-177 by irradiation of enriched ytterbium-17610.2174/1874471008666150312160855 ↗
16. Production of 177Lu for targeted radionuclide therapy: Available options10.1007/s13139-014-0315-z ↗
17. 2009 · 16
18. RIPL—Reference input parameter library for calculation of nuclear reactions and nuclear data evaluations10.1016/j.nds.2009.10.004 ↗
19. Excitation functions of 58Ni(n, charged particle) from threshold to 20 MeV using NLD models10.1007/s12648-020-01808-1 ↗
20. Evaluations of n + 27Al reaction in the energy range 0.1–200 MeV10.1007/s12648-019-01555-y ↗
21. EMPIRE: Nuclear reaction model code system for data evaluation10.1016/j.nds.2007.11.003 ↗
22. Cross sections of 56Fe(n, p)56Mn, 55Mn(n, p)55Cr, 52Cr(n, p)52V, 56Fe(n, α)53Cr, 55Mn(n, α)52V and 52Cr(n, α)49Ti reactions using phenomenological level density models from threshold to 20 MeV10.1016/j.apradiso.2020.109429 ↗