A review on non-leaching antibacterial bone cement for orthopedic surgery: From past to current insights
Source abstract
Abstract
Antibiotic-loaded bone cements are widely used in orthopedic surgery. However, they present issues such as a short antibiotic release time and antibiotic resistance. These challenges necessitate the development of novel antibacterial bone cements. Non-leaching bone cement containing antibacterial motifs represents a promising advancement in this direction. Antibacterial motifs are incorporated into the cement either covalently or non-covalently, and while they will not be released, they will still exhibit surface antibacterial activity. This review comprehensively examines the structure and antimicrobial activity of prevalent non-leaching antimicrobial bone cements. Additionally, it delves into the characteristics of current methods employed for detecting surface antimicrobial activity. Finally, the future research direction of non-leaching antibacterial bone cement is discussed, with a specific focus on innovative antibacterial motifs, the mechanisms underlying non-leaching antibacterial properties, and the potential synergies achievable by combining non-leaching antibacterial bone cement with traditional antibiotics.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Orthopedic Infections and Treatments · Orthopaedic implants and arthroplasty · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University 1 , Hefei, Anhui 230011, China
3 Institute of Advanced Technology, University of Science and Technology of China, Hefei, Anhui 230000, China
2 School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
Funding
Hefei Key Common Technology Research and Major Scientific Achievements Project · University Natural Science Project of Anhui Province · Fund of Anhui Medical University · Health Research Project of Anhui Province
References (56)
Show source-provided references
1. A review of bone cements as injectable materials for treatment of bone-related diseases: Current status and future developments10.32598/jrosj.9.1.855.1 ↗
2. High-strength calcium silicate-incorporated magnesium phosphate bone cement with osteogenic potential for orthopedic application10.1016/j.compositesb.2022.110324 ↗
3. Gelatin/gentamicin sulfate-modified PMMA bone cement with proper mechanical properties and high antibacterial ability10.1088/2053-1591/ac5e1f ↗
4. Acrylic bone cement: Current concept review10.1007/s12306-013-0293-9 ↗
5. In situ generated medical devices10.1002/adhm.201801066 ↗
6. Poly(methyl methacrylate) bone cement, its rise, growth, downfall and future10.1002/pi.6136 ↗
7. A preliminary review of modified polymethyl methacrylate and calcium-based bone cement for improving properties in osteoporotic vertebral compression fractures10.3389/fmats.2022.912713 ↗
8. Modifications of poly(methyl methacrylate) cement for application in orthopedic surgery10.1007/978-981-13-0950-2_7 ↗
9. Preparation, characterization, release kinetics, and in vitro cytotoxicity of calcium silicate cement as a risedronate delivery system10.1002/jbm.a.34908 ↗
10. Study of C3S/Nano-HAp/collagen composite bone cement10.2174/1573413709666131129000945 ↗
11. Recent developments on injectable calcium phosphate bone cement10.2174/1874464809666160802145629 ↗
12. Calcium phosphate bone cements: A comprehensive review10.1615/jlongtermeffmedimplants.v13.i1.50 ↗
13. Evaluation of calcium sulfate paste for augmentation of lumbar pedicle screw pullout strength10.1016/s1529-9430(02)00207-3 ↗
14. Depot effects of various antibiotics with Palacos resins
15. Antibiotics and bone cements: Experimental and clinical long-term observations10.3109/17453678008990768 ↗
16. Antibiotic depots10.1302/0301-620x.75b3.8496197 ↗
17. Gentamycin-PMMA-Kugeln bei chronischen Knocheninfektionen10.1007/bf01305623 ↗
18. Pharmacokinetic study of gentamicin-loaded cement in total hip replacements. Comparative effects of varying dosage10.1302/0301-620x.66b2.6707051 ↗
19. The use of antibiotic-loaded bone cement does not increase antibiotic resistance after primary total joint arthroplasty10.1007/s00167-021-06649-x ↗
20. Antimicrobials in polymethylmethacrylate: From prevention to prosthetic joint infection treatment: Basic principles and risk of resistance10.1186/s42836-023-00166-7 ↗
21. Dual antibiotic loaded bone cement in patients at high infection risks in arthroplasty: Rationale of use for prophylaxis and scientific evidence10.5312/wjo.v12.i3.119 ↗
22. In vitro release of antibiotics from commercial PMMA beads and articulating hip spacers10.1016/j.arth.2007.08.020 ↗
23. Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material10.1016/j.cis.2017.04.017 ↗
24. Risk assessment of antibiotic resistance development by antibiotic-loaded bone cements: Is it a clinical concern?10.1302/2058-5241.4.180104 ↗
25. Antibacterial properties of resin composites and dentin bonding systems10.1016/s0109-5641(02)00102-1 ↗
26. Influence of a polymerizable eugenol derivative on the antibacterial activity and wettability of a resin composite for intracanal post cementation and core build-up restoration10.1016/j.dental.2016.04.001 ↗
27. Recent developments in antimicrobial polymers: A review10.3390/ma9070599 ↗
28. Effect of polymerizable quaternary ammonium monomer MEIM-x’s alkyl chain length and content on bone cement’s antibacterial activity and physicochemical properties10.1016/j.jmbbm.2018.08.004 ↗
29. Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review10.5312/wjo.v13.i4.339 ↗
30. Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance10.1016/j.progpolymsci.2017.03.001 ↗
31. PMMA bone cement containing a quaternary amine comonomer with potential antibacterial properties10.1002/jbm.b.30925 ↗
32. Formulation and characterization of antimicrobial quaternary ammonium dendrimer in poly(methyl methcarylate) bone cement10.1002/jbm.b.33553 ↗
33. Preparation of bioactive and antibacterial PMMA-based bone cement by modification with quaternary ammonium and alkoxysilane10.1177/08853282211004413 ↗
34. Synthesis of imidazolium-containing mono-methacrylates as polymerizable antibacterial agents for acrylic bone cements10.1016/j.jmbbm.2017.06.003 ↗
35. Antibacterial adhesion of poly(methyl methacrylate) modified by borneol acrylate10.1021/acsami.6b10498 ↗
36. Mechanical and antibacterial properties of benzothiazole-based dental resin materials10.1080/09205063.2018.1429861 ↗
37. Preparation of antibacterial acrylic bone cement with methacrylate derived from benzothiazole10.1016/j.jmbbm.2021.104403 ↗
38. Synthesis of polymerizable quaternary thiazole salts and their application as antibacterial agents for dental resin10.1016/j.jmbbm.2022.105183 ↗
39. Preparation of new bio-based antibacterial acrylic bone cement via modification with a biofunctional monomer of nitrofurfuryl methacrylate10.1039/d2py00235c ↗
40. Sortase A inhibitors: Recent advances and future perspectives10.1021/acs.jmedchem.5b00779 ↗
41. Sortase A (SrtA) inhibitors as an alternative treatment for superbug infections10.1016/j.drudis.2021.03.019 ↗
42. Targeting bacterial Sortase A with covalent inhibitors: 27 new starting points for structure-based hit-to-lead optimization10.1021/acsinfecdis.9b00265 ↗
43. A novel antibacterial resin composite for improved dental restoratives10.1007/s10856-012-4629-z ↗
44. Developing a novel antibacterial dental resin composite with improved properties10.1177/0021998319839134 ↗
45. Therapeutic methacrylic comonomers for covalently controlled release from mechanically robust bone cement: Kinetics and structure–function relationships10.1021/acs.macromol.9b00368 ↗
46. The use of quaternised chitosan-loaded PMMA to inhibit biofilm formation and downregulate the virulence-associated gene expression of antibiotic-resistant staphylococcus10.1016/j.biomaterials.2011.09.084 ↗
47. Quaternised chitosan-loaded polymethylmethacrylate bone cement: Biomechanical and histological evaluations10.1016/j.jot.2013.06.002 ↗
48. A novel antibacterial zirconia-containing PMMA bone cement10.1016/j.jmbbm.2022.105135 ↗
49. A PMMA bone cement with improved antibacterial function and flexural strength10.1080/09205063.2022.2056943 ↗
50. Quantitative relationships between structure, aggregation properties and antimicrobial activity of quaternary ammonium bolaamphiphiles10.1135/cccc19951213 ↗
51. Bio-inspired stable antimicrobial peptide coatings for dental applications10.1016/j.actbio.2013.06.017 ↗
52. Hydrogel: A potential therapeutic material for bone tissue engineering10.1063/5.0035504 ↗
53. Degradable and comb-like PEG-based copolymers by nitroxide-mediated radical ring-opening polymerization10.1021/bm401157g ↗
54. Influence of N-acetyl cysteine (NAC) and 2-methylene-1,3-dioxepane (MDO) on the properties of polymethyl methacrylate (PMMA) bone cement10.1039/c9ra01638d ↗
55. Biodegradable phosphorylcholine copolymer for cardiovascular stent coating10.1039/d0tb00813c ↗
56. Comparison of antibacterial activity and biocompatibility of non-leaching nitrofuran bone cement loaded with vancomycin, gentamicin, and tigecycline10.1186/s13018-023-04055-2 ↗