Modification of microneedles using inkjet printing
Source abstract
Abstract
In this study, biodegradable acid anhydride copolymer microneedles containing quantum dots were fabricated by means of visible light dynamic mask micro-stereolithography-micromolding and inkjet printing. Nanoindentation was performed to obtain the hardness and the Young's modulus of the biodegradable acid anhydride copolymer. Imaging of quantum dots within porcine skin was accomplished by means of multiphoton microscopy. Our results suggest that the combination of visible light dynamic mask micro-stereolithography-micromolding and inkjet printing enables fabrication of solid biodegradable microneedles with a wide range of geometries as well as a wide range of pharmacologic agent compositions.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advancements in Transdermal Drug Delivery · Advanced Fluorescence Microscopy Techniques · Nanofabrication and Lithography Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
University of North Carolina and North Carolina State University 1 Joint Department of Biomedical Engineering, , Raleigh, NC 27695-7115, USA
North Carolina State University 2 Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, , Raleigh, NC 27695, USA
References (79)
Show source-provided references
1. Expert Opinion on Drug Delivery · 2010 · 7 · 2110.1517/17425241003628171 ↗
2. Advanced Drug Delivery Reviews · 2004 · 56 · 58110.1016/j.addr.2003.10.023 ↗
3. Nature Reviews Drug Discovery · 2004 · 3 · 11510.1038/nrd1304 ↗
4. British Journal of Dermatology · 2004 · 150 · 86910.1111/j.1365-2133.2004.05921.x ↗
5. Pharmaceutical Research · 2001 · 18 · 178910.1023/A:1013395102049 ↗
6. Journal of Drug Targeting · 2005 · 13 · 41510.1080/10611860500383705 ↗
7. Clinical Journal of Pain · 2008 · 24 · 58510.1097/AJP.0b013e31816778f9 ↗
8. Advanced Drug Delivery Reviews · 2007 · 59 · 152110.1016/j.addr.2007.08.019 ↗
9. Expert Opinion on Drug Delivery · 2005 · 2 · 53310.1517/17425247.2.3.533 ↗
10. Journal of Controlled Release · 2007 · 117 · 22710.1016/j.jconrel.2006.10.017 ↗
11. Journal of Controlled Release · 2004 · 97 · 50310.1016/S0168-3659(04)00171-3 ↗
12. Pharmaceutical Research · 2002 · 19 · 6310.1023/A:1013607400040 ↗
13. Vaccine · 2006 · 24 · 165310.1016/j.vaccine.2005.09.049 ↗
14. Pharmaceutical Research · 2007 · 24 · 136910.1007/s11095-007-9286-4 ↗
15. Advanced Functional Materials · 2011 · 21 · 46410.1002/adfm.201000966 ↗
16. Catalysis Today · 2011 · 161 · 9710.1016/j.cattod.2010.11.019 ↗
17. JOM · 2010 · 62 · 5610.1007/s11837-010-0109-4 ↗
18. Journal of Biomedical Materials Research Part B-Applied Biomaterials · 2009 · 89B · 2810.1002/jbm.b.31183 ↗
19. Polymer · 2010 · 51 · 214710.1016/j.polymer.2010.03.038 ↗
20. Chemistry of Materials · 2004 · 16 · 478310.1021/cm0496570 ↗
21. Analytical Chemistry · 2008 · 80 · 692810.1021/ac800604v ↗
22. Analytica Chimica Acta · 2004 · 518 · 7710.1016/j.aca.2004.04.065 ↗
23. Journal of Advanced Oxidation Technologies · 2010 · 13 · 172
24. 200710.1117/12.733253 ↗
25. Journal of Sol-Gel Science and Technology · 2010 · 54 · 15410.1007/s10971-010-2170-4 ↗
26. Flickinger · 2010
27. Biotechnol Journal · 2006 · 1 · 97610.1002/biot.200600123 ↗
28. Journal of Controlled Release · 2005 · 104 · 5110.1016/j.jconrel.2005.02.002 ↗
29. Journal of Investigative Dermatology · 2006 · 126 · 108010.1038/sj.jid.5700150 ↗
30. Journal of Controlled Release · 2007 · 117 · 22710.1016/j.jconrel.2006.10.017 ↗
31. Faraday Discussions · 2011 · 149 · 17110.1039/c005374k ↗
32. Journal of Pharmaceutical Sciences · 1965 · 54 · 17610.1002/jps.2600540203 ↗
33. Stewart · 1963
34. Molecules · 2005 · 10 · 12610.3390/10010126 ↗
35. I. Corzani, U. S. Patent No. 6403113 (11 June, 2002).
36. Biofabrication · 2009 · 1 · 04100110.1088/1758-5082/1/4/041001 ↗
37. Advanced Engineering Materials · 2010 · 12 · B77
38. AAPS PharmSciTech · 2010 · 11 · 30410.1208/s12249-010-9382-3 ↗
39. Pharmaceutical Research · 2011 · 28 · 30910.1007/s11095-010-0248-x ↗
40. American Journal of Dentistry · 1989 · 2 · 197
41. Journal of Clinical Dentistry · 2005 · 16 · S1
42. Pharmaceutical Research · 2011 · 28 · 4110.1007/s11095-010-0169-8 ↗
43. Photodiagnosis and Photodynamic Therapy · 2010 · 7 · 22210.1016/j.pdpdt.2010.09.001 ↗
44. Science · 1998 · 281
45. Angewandte Chemie International Edition · 2001 · 40 · 412810.1002/1521-3773(20011119)40:22<4128::AID-ANIE4128>3.0.CO;2-S ↗
46. Nature · 2001 · 413 · 45010.1038/35097256 ↗
47. Science · 2003 · 300 · 8010.1126/science.300.5616.80 ↗
48. Nanoscale · 2010 · 2 · 6010.1039/b9nr00178f ↗
49. Cancer Research · 2007 · 67 · 113810.1158/0008-5472.CAN-06-1185 ↗
50. Bioconjugate Chemistry · 2007 · 18 · 139110.1021/bc060367e ↗
51. Biochemical and Biophysical Research Communications · 2004 · 325 · 73910.1016/j.bbrc.2004.10.099 ↗
52. Journal of Nanoscience and Nanotechnology · 2010 · 10 · 52010.1166/jnn.2010.1723 ↗
53. Nano Letters · 2007 · 7 · 306510.1021/nl071546n ↗
54. Nature Protocols · 2008 · 3 · 8910.1038/nprot.2007.478 ↗
55. International Journal of Advanced Manufacturing Technology · 2010 · 46 · 15110.1007/s00170-009-2065-0 ↗
56. Biomicrofluidics · 2011 · 5 · 01341510.1063/1.3569945 ↗
57. 2011
58. 2011
59. 2006
60. Nanotechnology · 2009 · 20 · 21510110.1088/0957-4484/20/21/215101 ↗
61. 2011
62. Skin Pharmacology and Physiology · 2008 · 21 · 16610.1159/000131080 ↗
63. Monteiro-Riviere · 200710.3109/9781420045154 ↗
64. Toxicological Sciences · 2006 · 81 · 15910.1093/toxsci/kfj122 ↗
65. Journal of Materials Research · 1992 · 7 · 156410.1557/JMR.1992.1564 ↗
66. Current Problems in Dermatology · 1978 · 7 · 39
67. Tumbleson · 1996 · 42510.1007/978-1-4615-5885-9 ↗
68. Tumbleson · 1986 · 641
69. Pond · 2001
70. Nature · 2008 · 452 · 58010.1038/nature06917 ↗
71. Science · 2003 · 300 · 143410.1126/science.1083780 ↗
72. Journal of Controlled Release · 2007 · 122 · 37510.1016/j.jconrel.2007.05.031 ↗
73. Journal of Controlled Release · 2005 · 104 · 5110.1016/j.jconrel.2005.02.002 ↗
74. Journal of the Korean Physical Society · 2010 · 56 · 122310.3938/jkps.56.1223 ↗
75. 1980 · 269
76. Toxicology and Applied Pharmacology · 2008 · 228 · 20010.1016/j.taap.2007.12.022 ↗
77. General discussion10.1039/c0fd90010a ↗
78. Journal of Neurophysiology · 2004 · 91 · 190810.1152/jn.01007.2003 ↗
79. IEEE Journal of Selected Topics in Quantum Electronics · 2010 · 16 · 74810.1109/JSTQE.2009.2038597 ↗