Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors
Source abstract
Abstract
Inefficient vascularization hinders the optimal transport of cell nutrients, oxygen, and drugs to cancer cells in solid tumors. Gradients of these substances maintain a heterogeneous cell-scale microenvironment through which drugs and their carriers must travel, significantly limiting optimal drug exposure. In this study, we integrate intravital microscopy with a mathematical model of cancer to evaluate the behavior of nanoparticle-based drug delivery systems designed to circumvent biophysical barriers. We simulate the effect of doxorubicin delivered via porous 1000 x 400 nm plateloid silicon particles to a solid tumor characterized by a realistic vasculature, and vary the parameters to determine how much drug per particle and how many particles need to be released within the vasculature in order to achieve remission of the tumor. We envision that this work will contribute to the development of quantitative measures of nanoparticle design and drug loading in order to optimize cancer treatment via nanotherapeutics.
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Research context
OpenAlex topics: Mathematical Biology Tumor Growth · Cancer Cells and Metastasis · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
The Methodist Hospital Research Institute 1 Department of Nanomedicine, , 6670 Bertner Avenue, Houston, Texas, 77030, USA
University of California 2 Department of Mathematics, , Irvine, California, 92697, USA
Heriot-Watt University 3 Institute of Petroleum Engineering, , Edinburgh, Scotland, UK
University of Dundee 4 Division of Mathematics, , Dundee, Scotland, UK
University of New Mexico 5 Department of Pathology. , Albuquerque, New Mexico, 87106, USA
University of New Mexico 6 Chemical Engineering, , Albuquerque, New Mexico, 87106, USA
University of Louisville 7 Department of Bioengineering, , 419 Lutz Hall, Louisville, Kentucky 40208, USA
University of Louisville 8 James Graham Brown Cancer Center, , 419 Lutz Hall, Louisville, Kentucky 40208, USA
Funding
National Institutes of Health
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