Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

D. Doria; K. F. Kakolee; S. Kar; S. K. Litt; F. Fiorini; H. Ahmed; S. Green; J. C. G. Jeynes; J. Kavanagh; D. Kirby; K. J. Kirkby; C. L. Lewis; M. J. Merchant; G. Nersisyan; R. Prasad; K. M. Prise; G. Schettino; M. Zepf; M. Borghesi

doi:10.1063/1.3699063

journal article·2012-03-01Open access

Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

D. Doria, K. F. Kakolee, S. Kar, S. K. Litt, F. Fiorini, H. Ahmed, S. Green, J. C. G. Jeynes, J. Kavanagh, D. Kirby, K. J. Kirkby, C. L. Lewis, M. J. Merchant, G. Nersisyan, R. Prasad, K. M. Prise, G. Schettino, M. Zepf, M. Borghesi

AIP Advances· Volume 2· Issue 1

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Source abstract

Abstract

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

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Research context

OpenAlex topics: Laser-Plasma Interactions and Diagnostics · Radiation Therapy and Dosimetry · Laser-induced spectroscopy and plasma

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Queen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UK

University of Birmingham 2 School of Physics and Astronomy, , B15 2TT, UK

University Hospital Birmingham 3 Hall Edwards Radiotherapy Research Group, Dept. of Medical Physics, , B15 2TH, UK

University of Surrey 4 Ion Beam Centre, Advanced Technology Institute, , Guildford GU2 7XH, UK

Queen's University Belfast 5 Centre for Cancer Research and Cell Biology, , BT9 7BL, UK

Funding

Engineering and Physical Sciences Research Council

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