journal article·2025-09

Decision Support System for Safe‐and‐Sustainable‐by‐Design Advanced Materials: Case Study Demonstration

Veronique Adam, Veronica Di Battista, Fabienne Testard, Michael Persson, Daniel Persson, Dorra Gargouri, Arianna Filoramo, Roland Grafström, Pekka Kohonen, Vesa Hongisto, Mona Conolly, José Maria Navas, Lars Michael Skjolding, Agnieszka Gajewicz‐Skretna, Pernille Høgh Danielsen, Ulla Vogel, Keld Alstrup Jensen, Eugene van Someren, Susan Dekkers, Otmar Schmid, Wendel Wohlleben, Blanca Suarez Merino

Advanced Sustainable Systems· Volume 9· Issue 9
Publisher page

Abstract

Abstract In the context of the EU Chemicals Strategy for Sustainability toward a Toxic‐free Environment, and in the aim to facilitate Safe‐and‐Sustainable‐by‐Design (SSbD) development of new materials and products, the EU‐funded project HARMLESS built a Decision Support System (DSS) to support innovators in SSbD assessments of products at early design stages. The HARMLESS DSS is tailored to enable Advanced Materials (AdMa) screening, using a combination of New Approach Methodologies and guided by Integrated Approaches to Testing and Assessment. Three online tools for SSbD screenings are developed and tested on case study materials, namely: Advanced Materials Earliest Assessment; Warning flags, design Advice, Screening Priorities; and Alternative SSbD Inspector. The following case studies are assessed: oxide perovskites for automotive catalysts, imogolites for agricultural solutions, aerogel mats for facade insulation, and colloidal silica for paint formulations. The case study materials are provided by both large and small enterprises, they represent diverse industry sectors and different stages in the value chain. Results show the DSS ability to guide innovators in developing SSbD AdMa, by facilitating the assessment of most SSbD dimensions and visualizing the results in a comprehensive, yet detailed way, enabling their own balancing of SSbD benefits and trade‐offs.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Ergonomics and Human Factors · Chemistry and Chemical Engineering · Pigment Synthesis and Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

TEMAS Solutions Laetteweg 5 Hausen 5212 Switzerland

BASF SE Carl‐Bosch‐Str. 38 67056 Ludwigshafen Germany

CEA Saclay CNRS NIMBE LIONS Université Paris‐Saclay Gif‐Sur‐Yvette 91191 Cedex France

Chalmers Industriteknik Sven Hultins Plats 1 Gothenburg 412 58 Sweden

Nouryon AB Nouryon Pulp and Performance Chemicals AB Bohus 445 80 Sweden

CEA Saclay CNRS NIMBE LICSEN Université Paris‐Saclay Gif‐Sur‐Yvette 91191 Cedex France

Department of Toxicology Misvik Biology Oy Turku 20520 Finland

Institute of Environmental Medicine Karolinska Institutet Nobels väg 13 Stockholm 17177 Sweden

Misvik Biology Oy Turku 20520 Finland

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) CSIC Ctra. de la Coruña, km. 7,5 Madrid 28040 Spain

Department of Environmental and Resource Engineering Technical University of Denmark Bygningstorvet, Building 115 Kgs Lyngby DK‐2800 Denmark

Laboratory of Environmental Chemoinformatics Faculty of Chemistry University of Gdansk Wita Stwosza 63 Gdansk 80‐309 Poland

National Research Centre for the Working Environment Copenhagen 2100 Denmark

Risk Analysis for Prevention, Innovation & Development TNO Princetonlaan 6 Utrecht 3584 CB The Netherlands

Institute of Lung Health and Immunity (LHI) Helmholtz Munich Comprehensive Pneumology Center (CPC‐M) Germany Member of the German Center for Lung Research (DZL) Ingolstaedter Landstrasse 1 85764 Neuherberg Germany

Funding

Horizon 2020 Framework Programme

References (73)

Show source-provided references
1. European Commission · 2020
2. European Commission Commission Recommendation of 8.12.2022 Establishing a European Assessment Framework for ‘Safe and Sustainable by Design’ Chemicals and Materials European Commission Brussels2022 C(2022) 8854 final.
3. European Commission · 2023
4. 3rd Stakeholder Workshop on “Safe and Sustainable by Design” Case Studies (Day 1/2) https://www.youtube.com/watch?v=OcGydn2wyE0(accessed July 2023).
5. 3rd Stakeholder Workshop on “Safe and Sustainable by Design” Case Studies (Day 2/2) https://www.youtube.com/watch?v=SKTrtKrAr6Y(accessed July 2023).
6. Commission E. · 2024
7. RTD Research and Innovation 5th Stakeholder workshop on ‘Safe and sustainable by design’ https://research‐and‐innovation.ec.europa.eu/events/upcoming‐events/5th‐stakeholder‐workshop‐safe‐and‐sustainable‐design‐2024‐12‐05_en(accessed December 2024).
8. Feedback from Stakeholders during the Second Testing Period – Case Studies https://www.canva.com/design/DAGZAIrgCqc/ni‐TZw3FwLwIoVdJX7EABw/watch?utm_content=DAGZAIrgCqc&utm_campaign=designshare&utm_medium=link2&utm_source=uniquelinks&utlId=h7728f7b80e(accessed May 2025).
9. Feedback from Stakeholders during the Second Testing Period – Applicability of the Frameworkhttps://www.canva.com/design/DAGZEe9pvkc/Lcr1AvgSYOk8pAWit9zrVg/watch?utm_content=DAGZEe9pvkc&utm_campaign=designshare&utm_medium=link2&utm_source=uniquelinks&utlId=hab938617c5(accessed May 2025).
10. OECD Safe(r) and Sustainable Innovation Approach (SSIA) https://www.oecd.org/en/topics/sub‐issues/nanomaterials‐and‐advanced‐materials/safer‐and‐sustainable‐innovation‐approach‐ssia‐nano‐enabled‐and‐other‐emerging‐materials.html(accessed April 2023).
11. J.Prinz G.Nagel S.Dekkers E.vanSomeren V.Adam V.Di Battista B.Suarez Merino W.Wohlleben M.Persson A.Baun O.Schmid A.Haase HARMLESS Early Warning System for Advanced Materials Advanced Sustainable Systems2025 DOI: 10.1002/adsu.20250021710.1002/adsu.202500217 ↗
12. S.Dekkers V.Adam V.Di Battista A.Haase J.Prinz G.Nagel W.Fransman M.Persson B.Suarez Merino W.Wohlleben O.Schmid E.vanSomeren Safe‐and‐Sustainable‐by‐Design Approach and Decision Support System for Advanced Nanomaterials In prep.
13. 10.1016/j.impact.2021.10033510.1016/j.impact.2021.100335 ↗
14. 10.1016/j.impact.2022.10038510.1016/j.impact.2022.100385 ↗
15. 10.1039/D3EN00831B10.1039/D3EN00831B ↗
16. United Nations Transforming our World: The 2030 Agenda for Sustainable Development 2015https://sdgs.un.org/publications/transforming‐our‐world‐2030‐agenda‐sustainable‐development‐17981(accessed June 2025).
17. 10.1038/nature0089310.1038/nature00893 ↗
18. 10.1002/adfm.20210208910.1002/adfm.202102089 ↗
19. 10.1021/acs.iecr.7b0325110.1021/acs.iecr.7b03251 ↗
20. 10.1039/C6FD00034G10.1039/C6FD00034G ↗
21. Yuan P. · 2016
22. 10.1039/D1QM00617G10.1039/D1QM00617G ↗
23. 10.1080/00380768.1962.1043099310.1080/00380768.1962.10430993 ↗
24. Picot P. · Use of aluminosilicate polymers as an active ingredient against phytopathogenic microorganisms · 2024
25. European Commission · Off.l J. Eur. Communities: Legis. · 2011 · 342
26. ISO ISO 80004‐1:2023 Nanotechnologies – Vocabulary – Part 1: Core vocabulary International Organization for Standardisation Geneva Switzerland2023.
27. 10.1016/j.impact.2021.10036610.1016/j.impact.2021.100366 ↗
28. L.Traas R.Vanhauten GRACIOUS Framework Blueprint V1 https://zenodo.org/records/5497615(accessed January 2025).
29. 10.1021/acsnano.4c1013510.1021/acsnano.4c10135 ↗
30. 10.1016/S1381-1169(02)00177-210.1016/S1381-1169(02)00177-2 ↗
31. 10.6028/jres.058.01010.6028/jres.058.010 ↗
32. TNO “Substance Information System – A Smart Search Engine Providing and Integrative View on occupational human health risk information ”https://diamonds.tno.nl/projects/sis(accessed March 2025).
33. ECHA “Search for chemicals ”https://echa.europa.eu/information‐on‐chemicals(accessed: June 2025).
34. 10.1016/S0959-6526(00)00082-210.1016/S0959-6526(00)00082-2 ↗
35. European Commission “Commission proposes new Euro 7 standards to reduce pollutant emissions from vehicles and improve air quality ”https://ec.europa.eu/commission/presscorner/detail/en/ip_22_6495(accessed: June 2025).
36. 10.1089/aivt.2021.000910.1089/aivt.2021.0009 ↗
37. 10.1039/D3EN00685A10.1039/D3EN00685A ↗
38. 10.1088/1742-6596/838/1/01203310.1088/1742-6596/838/1/012033 ↗
39. 10.1039/C7EN00346C10.1039/C7EN00346C ↗
40. 10.1016/j.bioelechem.2025.10892710.1016/j.bioelechem.2025.108927 ↗
41. OECD Test No. 202: Daphnia sp. Acute Immobilisation Test OECD Guidelines for the Testing of Chemicals Section 2 OECD Publishing Paris France2011.
42. OECD Test No. 249: Fish Cell Line Acute Toxicity‐The RTgill‐W1 cell line assay OECD Guidelines for the Testing of Chemicals Section 2 OECD Publishing Paris France2004.
43. OECD Test No.: Fish Cell Line Acute Toxicity – The RTgill‐W1 cell line assay OECD Guidelines for the Testing of Chemicals Section 2 OECD Publishing Paris France2021.
44. WBCSD Portfolio Sustainability Assessment v2.0‐A Framework Developed by Leading Chemical Companies for All Sectors WBCSD Geneva Switzerland2023.
45. 10.1016/j.etap.2019.10330310.1016/j.etap.2019.103303 ↗
46. European Committee for Standardization Workplace Exposure‐Measurement of Dustiness of Bulk Materials That Contain or Release Respirable NOAA and Other Respirable Particles‐Part 1: Requirements and Choice of Test Methods CEN Brussels 2019 EN 17199‐1:2019 .
47. 10.1093/annweh/wxy00210.1093/annweh/wxy002 ↗
48. 10.1093/annweh/wxac087.13810.1093/annweh/wxac087.138 ↗
49. 10.1180/claymin.2009.044.1.13510.1180/claymin.2009.044.1.135 ↗
50. Jaurand M. C. · 2016 · 485
51. 10.1039/D1NR06462B10.1039/D1NR06462B ↗
52. 10.1039/D1EN00405K10.1039/D1EN00405K ↗
53. 10.1080/17435390.2020.177178610.1080/17435390.2020.1771786 ↗
54. 10.1007/s11051-008-9420-110.1007/s11051-008-9420-1 ↗
55. 10.1016/j.progpolymsci.2014.04.00410.1016/j.progpolymsci.2014.04.004 ↗
56. 10.1016/j.etap.2019.10326610.1016/j.etap.2019.103266 ↗
57. 10.1002/smll.20231115510.1002/smll.202311155 ↗
58. Rasmussen K. · 2013
59. 10.1016/j.enbuild.2010.12.01210.1016/j.enbuild.2010.12.012 ↗
60. 10.1006/rtph.2000.141810.1006/rtph.2000.1418 ↗
61. 10.1006/rtph.2001.152310.1006/rtph.2001.1523 ↗
62. 10.1016/j.impact.2018.12.00310.1016/j.impact.2018.12.003 ↗
63. 10.1186/s12989-017-0210-810.1186/s12989-017-0210-8 ↗
64. Rubalcaba A. · 2023 · 107
65. 10.1016/j.chemosphere.2014.02.00510.1016/j.chemosphere.2014.02.005 ↗
66. European Commission · 2022
67. 10.1007/s11367-008-0038-410.1007/s11367-008-0038-4 ↗
68. 10.1007/s11367-019-01583-010.1007/s11367-019-01583-0 ↗
69. E.Saouter F.Biganzoli L.Ceriani D.Versteeg E.Crenna L.Zampori S.Sala R.Pant Environmental Footprint: Update of Life Cycle Impact Assessment Methods – Ecotoxicity Freshwater Human Toxicity Cancer and Non‐Cancer EUR 29495 EN Publications Office Of The European Union Luxembourg2018.
70. 10.1016/j.jclepro.2018.09.18710.1016/j.jclepro.2018.09.187 ↗
71. Oomen A. G. · 2022
72. OECD Early Awareness and Action System for Advanced Materials (Early4AdMa) Pre‐regulatory and Anticipatory Risk Governance Tool to Advanced Materials Series on the Safety of Manufactured Nanomaterials No. 108. ENV/CBC/MONO(2023)35 OECD Publishing Paris2023.
73. 10.1016/j.cesys.2023.10013210.1016/j.cesys.2023.100132 ↗