PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease
Abstract
Research context
OpenAlex topics: Genetic Neurodegenerative Diseases · Nuclear Structure and Function · Ubiquitin and proteasome pathways
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Affiliations
Interdisciplinary Research Center on Biology and Chemistry State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai China
Key Laboratory of Hunan Province in Neurodegenerative Disorders Department of Neurology & National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha Hunan China
State Key Laboratory of Medical Proteomics and Shenzhen Key Laboratory of Functional Proteomics Department of Chemistry and Research Center for Chemical Biology and Omics Analysis School of Science and Guangming Advanced Research Institute Southern University of Science and Technology Shenzhen China
Bio‐X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai China
Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University Shanghai China
Department of Pathology Xiangya Hospital Central South University Changsha Hunan China
Department of Geriatrics Xiangya Hospital Central South University Changsha Hunan China
State Key Laboratory of Membrane Biology Peking‐Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies School of Life Sciences Peking University Beijing China
Changping Laboratory Beijing China
Shanghai Academy of Natural Sciences (SANS) Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai China
Funding
National Natural Science Foundation of China