journal article·2026-07-13Open access

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen

Abstract

ABSTRACT Infectious diseases can cause lasting immune disturbances, but whether they contribute to later inflammatory bowel disease (IBD) is unclear. Hospital‐treated infections may be especially informative because they reflect substantial immune challenge, yet their relation to IBD risk and the role of host genetics remain poorly defined. It examines hospital‐treated infections and incident IBD in a prospective cohort and integrates gene‐environment interaction analyses to identify susceptibility pathways and develop a post‐infection risk score. Hospital‐treated infections of multiple pathogen types and sites were associated with higher subsequent IBD risk. This association is stronger in carriers of immune‐related risk variants, with Crohn's disease linked mainly to innate immune and autophagy pathways and ulcerative colitis to JAK‐STAT, T‐cell differentiation, and chemokine signaling. An Infection IBD Score based on 44 immune‐related genes stratified post‐infection risk. These findings support infections as triggers of IBD in genetically susceptible individuals and highlight a potential tool for risk stratification.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Inflammatory Bowel Disease · Gut microbiota and health · Neutrophil, Myeloperoxidase and Oxidative Mechanisms

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Gastroenterology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai P. R. China

Department of Gastroenterology The Third Xiangya Hospital of Central South University Changsha P. R. China

Xiangya School of Public Health Central South University Changsha P. R. China

Department of Surgery Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA

Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden

Department of Big Data in Health Science School of Public Health and The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang P. R. China

Unit of Cardiovascular and Nutritional Epidemiology Institute of Environmental Medicine, Karolinska Institutet Stockholm Sweden

Department of Paediatrics Örebro University Hospital Örebro Sweden

Department of Gastroenterology Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University Hangzhou P. R. China

Department of Infectious Diseases, Faculty of Medicine, Centro Hospitalar S. João, Nephrology Research and Development Unit University of Porto Porto Portugal

Department of Gastroenterology Université De Lorraine CHRU Nancy France

Department of Dermatology Xiangya Hospital Central South University Changsha Hunan P. R. China

CINTESIS@RISE Department Faculdade De Medicina da Universidade do Porto Porto Portugal

Postdoctoral Station of Clinical Medicine The Third Xiangya Hospital of Central South University Changsha P. R. China

Funding

National Natural Science Foundation of China · China Postdoctoral Science Foundation

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