Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays (Adv. Sci. 39/2026)

Ectodermal Epithelial Organoid Establishment through Modeling Development Inspired by the notion of modeling development, ectodermal epithelial organoids are established by downregulation of the TGF-β signaling pathway. Organoids closely recapitulate the cellular and structural characteristics of oral mucosal tissues. Organoid models greatly facilitate the toxicological screening of pharmaceuticals and biomaterials. More details can be found in the Research Article by Mingming Xu, Ying Huang, Xuliang Deng, and co-workers (DOI: 10.1002/advs.202522709).