journal article·2026-07Open access

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway (Adv. Sci. 38/2026)

Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen

Advanced Science· Volume 13· Issue 38

Abstract

pH-Responsive Hydrogel for Targeted Reprogramming of Macrophage in Lymphoma Microenvironmen An engineered drug delivery system was developed by coupling M2pep-EVs and pH-responsive TP hydrogel to selectively target tumor associated macrophage in lymphoma microenvironment. It provides a paradigm to concurrently disrupt the immunosuppressive niche and enhance intrinsic drug activity for refractory lymphoma treatment. More details can be found in the Research Article by Yin Tong, Tong Chen, and co-workers (DOI: 10.1002/advs.202502791).
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Research context

OpenAlex topics: Immune cells in cancer · Nanoplatforms for cancer theranostics · Protein Degradation and Inhibitors

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