Calcium‐Mechanochemistry Enabled Ketone Synthesis From Organic Iodides and Carboxylic Acids
Source abstract
Abstract
ABSTRACT Organocalcium reagents possess a reactivity profile distinct from that of classical organolithium and Grignard reagents, yet their synthetic potential remains underexplored. Here we report that mechanochemically generated organocalcium species exhibit an unusual chemoselectivity toward carboxylate salts, enabling the direct and selective transformation of carboxylates into ketones without overaddition, a persistent limitation of conventional organometallic chemistry. Commercially available calcium metal is directly activated by ball milling with aryl iodides to generate reactive organocalcium intermediates under solvent‐minimized and ambient conditions. This protocol exhibits broad substrate scope, excellent chemoselectivity, and high functional‐group tolerance. Moreover, the reaction can be extended to the direct use of carboxylic acids, enabling a one‐step synthesis of pharmaceutically and industrially relevant ketones.
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Research context
OpenAlex topics: Coordination Chemistry and Organometallics · Crystallography and molecular interactions · Catalytic Cross-Coupling Reactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Pharmacy Xi'an Jiaotong University Xi'an China
School of Chemical Engineering and Pharmacy Pharmaceutical Research Institute Wuhan Institute of Technology Wuhan China
Xi'an Jiaotong University Suzhou Academy Suzhou China
Department of Pharmacy The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China
Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an China
Department of Chemistry University College London London UK
Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine School of Basic Sciences and Forensic Medicine Hangzhou Medical College Hangzhou Zhejiang China
Funding
National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities
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