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journal article·2026-07Open access

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound (Adv. Sci. 37/2026)

Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa

Advanced Science· Volume 13· Issue 37
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Source abstract

Abstract

Noninvasive Focal Gene Delivery Drug delivery to the brain is limited by the blood-brain barrier. In their Research Article (DOI: 10.1002/advs.75307), José A. Obeso, Javier Blesa, and co-workers demonstrate successful barrier opening and focal delivery of adeno-associated viral vectors to the cerebellum after systemic injection using low-intensity focused ultrasound in macaques, enabling noninvasive gene therapy approaches.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Ultrasound and Hyperthermia Applications · Virus-based gene therapy research · Nerve injury and regeneration

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