Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine (Adv. Sci. 37/2026)

Xinran Liu; Xin Chen; Qingyang Zhao; Weikang Tan; Lingrui Zhu; Kin Liao; Vincent Chan; Nicolae Goga; Winfred O. Larkotey; Yang Li; Yinghui Shi; Wenya Shu; Lin Wang; Weiqing Wang; Tian Jian Lu; Yulong Han

doi:10.1002/advs.76115

journal article·2026-07Open access

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine (Adv. Sci. 37/2026)

Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han

Advanced Science· Volume 13· Issue 37

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Source abstract

Abstract

Multiscale Architecture and Mechanics of the Cell Nucleus This cover illustrates the cell nucleus as a dynamic, multiscale mechanical hub. Chromatin loops, nuclear pores, and the lamina form an integrated architecture that senses cytoskeletal forces, while surrounding pathogens and engineered nanocarriers highlight disease and nanomedicine contexts. The image emphasizes how nuclear structure, mechanics, and transport barriers shape cellular function and therapeutic design. More details can be found in the Review by Lin Wang, Yulong Han, and co-workers (DOI: 10.1002/advs.75470).

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Cellular Mechanics and Interactions · Microtubule and mitosis dynamics · Advanced Materials and Mechanics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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