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journal article·2026-06-22Open access

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer

Advanced Science
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Abstract

ABSTRACT The surface protein CD177 on human neutrophil granulocytes is linked to tissue infiltration. In most individuals, circulating neutrophils comprise distinct fractions of CD177‐expressing (CD177 + ) and non‐expressing (CD177 − ) cells, which differ functionally and influence disease outcomes. Currently, CD177 is considered a dynamic activation marker ultimately expressed by most neutrophils. Here, we show that, instead, CD177 − ‐neutrophils represent a stable subpopulation that never acquires CD177. CD177 + ‐ to CD177 − ‐neutrophil ratios persist over time in individuals, regardless of circadian rhythms or inflammation. Neutrophils remain CD177 − during in vitro stimulation and are morphologically similar to CD177 + ‐cells, but differ markedly regarding protein composition. Following stem cell transplantation, the host bone marrow defines the CD177‐pattern of mature neutrophils. Functionally, CD177 − neutrophils display pro‐tumoral properties, including elevated arginase expression and enhanced tumor‐supporting activity, are enriched in human head‐and‐neck cancer tissues, and associated with adverse clinical outcomes. Hence, CD177‐expression or ‐absence defines stable human neutrophil subtypes with distinct functions.
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Research context

OpenAlex topics: Neutrophil, Myeloperoxidase and Oxidative Mechanisms · Immune cells in cancer · Blood disorders and treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute For Experimental Immunology and Imaging University Hospital University of Duisburg‐Essen Essen Germany

Leibniz‐Institut Für Analytische Wissenschaften – ISAS – e.V. Dortmund Germany

Department of Otorhinolaryngology University Hospital Essen University Duisburg‐Essen Essen Germany

Institute For Transfusion Medicine University Hospital Essen University of Duisburg‐Essen Essen Germany

Department of Hematology and Stem Cell Transplantation West‐German Cancer Center University Hospital Essen Essen Germany

Department of Neurology University Hospital Essen University of Duisburg‐Essen Essen Germany

Academy for Multidisciplinary Studies Capital Normal University Beijing China

Institute of Cardiovascular Physiology and Pathophysiology Biomedical Center Ludwig‐Maximilians‐Universität München Munich Germany

Institute For Experimental Pathology Centre of Molecular Biology of Inflammation University of Münster Münster Germany

Partner Site Düsseldorf/Essen German Cancer Consortium (DKTK) Essen Germany

West German Cancer Center University Hospital Essen Essen Germany

Center For Molecular Biotechnology University Hospital Essen Essen Germany

Faculty of Chemistry University of Duisburg‐Essen Essen Germany

Medical Faculty Ruhr‐Universität Bochum Bochum Germany

Funding

Deutsche Forschungsgemeinschaft · Bundesministerium für Forschung, Technologie und Raumfahrt · Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen · Deutsche Krebshilfe

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