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journal article·2026-06-19Open access

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng

Advanced Science
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Abstract

ABSTRACT Rapid and sensitive diagnostic strategies are crucial for the prevention and control of tuberculosis (TB). Unlike the invasive TB diagnostic strategy in the clinic, here we introduce a convenient, portable, and non‐invasive system that is constructed by Ag@Au nanoflower (NF) array‐based sensing facemask and catalytic/plasmonic urchin‐shaped Au─Ag embedded covalent organic framework (U@COF) sensor. This system detects TB antigen ESAT‐6/CFP‐10 complex in droplet or sputum samples from a variety of clinical settings. Practical analysis of clinical samples demonstrates this assay is capable of classifying the negative ( N = 12 ) and positive ( N = 17 ) TB patients with satisfactory sensitivity (76.5%) and specificity (100%), among whom two TB‐infected patients (TB3 and TB5) missed by droplet analysis are successfully identified by sputum analysis. More importantly, two cases with abnormally elevated ESAT‐6/CFP‐10 levels are screened out from close contacts of TB patients ( N = 6 ), which is highly suggestive of TB infection (Close contacts 3 and 4). This portable mask is suitable for rapid diagnosis of TB infection in patients with cough, particularly for screening of TB close contacts.
Source: crossref · Quality: baseline

Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Polydiacetylene-based materials and applications · Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs The Fifth Affiliated Hospital College of Pharmacy Jinan University Guangzhou China

The First Dongguan Affiliated Hospital Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics School of Medical Technology Guangdong Medical University Dongguan China

The Ninth People's Hospital of Dongguan Dongguan China

College of Chemistry and Materials Science Jinan University Guangzhou China

Institute for Safflower Industry Research Key Laboratory of Xinjiang Phytomedicine Resource and Utilization Ministry of Education School of Pharmacy Shihezi University Shihezi China

School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China

Funding

National Natural Science Foundation of China · Basic and Applied Basic Research Foundation of Guangdong Province

References (45)

Show source-provided references
1. 10.1016/S0140‐6736(24)02479‐610.1016/S0140‐6736(24)02479‐6 ↗
2. 10.1016/S2214‐109X(25)00105‐610.1016/S2214‐109X(25)00105‐6 ↗
3. Insights From the 2024 WHO Global Tuberculosis Report –More Comprehensive Action, Innovation, and Investments Required for Achieving WHO End TB Goals10.1016/j.ijid.2024.107325 ↗
4. 10.1093/inthealth/ihae05910.1093/inthealth/ihae059 ↗
5. 10.1016/j.ijid.2022.02.04710.1016/j.ijid.2022.02.047 ↗
6. 10.1016/S1473‐3099(21)00261‐910.1016/S1473‐3099(21)00261‐9 ↗
7. 10.1016/j.ijtb.2022.03.01110.1016/j.ijtb.2022.03.011 ↗
8. 10.1080/14787210.2020.181056510.1080/14787210.2020.1810565 ↗
9. 10.1038/s41467‐022‐35453‐510.1038/s41467‐022‐35453‐5 ↗
10. 10.1088/1752‐7163/aa88e410.1088/1752‐7163/aa88e4 ↗
11. 10.1016/j.jinf.2023.05.00710.1016/j.jinf.2023.05.007 ↗
12. 10.1016/j.cmi.2022.07.00510.1016/j.cmi.2022.07.005 ↗
13. 10.1021/acsami.2c1644610.1021/acsami.2c16446 ↗
14. 10.1126/science.adn647110.1126/science.adn6471 ↗
15. 10.1002/smll.20240867010.1002/smll.202408670 ↗
16. In Situ Collection and SERS Detection of Nitrite in Exhalations on Facemasks Based on Wettability Differences10.1021/acssensors.4c00857 ↗
17. Human Exhaled Air Energy Harvesting With Specific Reference to PVDF Film
18. 10.1007/s10404‐007‐0248‐210.1007/s10404‐007‐0248‐2 ↗
19. 10.1021/acs.analchem.5c0489610.1021/acs.analchem.5c04896 ↗
20. Dual‐Enhanced SERS Satellite Immuno‐Nanocomplex for Multiple PSA‐Mediated PHI Assay Toward Clinical Prostate Cancer Screening10.1002/advs.202411747 ↗
21. 10.1021/acs.analchem.2c0564010.1021/acs.analchem.2c05640 ↗
22. 10.1016/j.cej.2023.14752810.1016/j.cej.2023.147528 ↗
23. 10.1016/j.apsb.2022.08.02410.1016/j.apsb.2022.08.024 ↗
24. 10.1016/j.saa.2025.12606110.1016/j.saa.2025.126061 ↗
25. A Ratiometric SERS Strategy Based on a WO3/W18O49 Homojunction Substrate With Built‐In Raman Internal Standard for Accurate Trace Antibiotic Detection10.1021/acs.analchem.5c03884 ↗
26. 10.1002/advs.20240983810.1002/advs.202409838 ↗
27. 10.1016/j.saa.2021.12053410.1016/j.saa.2021.120534 ↗
28. 10.1016/j.saa.2023.12283410.1016/j.saa.2023.122834 ↗
29. 10.1016/j.saa.2022.12164410.1016/j.saa.2022.121644 ↗
30. 10.1021/acs.analchem.4c0137610.1021/acs.analchem.4c01376 ↗
31. 10.1002/smll.20250184610.1002/smll.202501846 ↗
32. 10.3389/fnut.2022.107529610.3389/fnut.2022.1075296 ↗
33. 10.1021/acsami.5c1346510.1021/acsami.5c13465 ↗
34. Pyridine‐Bridged Covalent Organic Frameworks With Adjustable Band Gaps as Intelligent Artificial Enzymes for Light‐Augmented Biocatalytic Sensing10.1002/smll.202401673 ↗
35. Solutions Are the Problem: Ordered Two‐Dimensional Covalent Organic Framework Films by Chemical Vapor Deposition10.1021/acsnano.3c06142 ↗
36. 10.1097/MD.000000000000935010.1097/MD.0000000000009350 ↗
37. 10.1016/j.bios.2018.08.06810.1016/j.bios.2018.08.068 ↗
38. 10.1021/acs.analchem.3c0163110.1021/acs.analchem.3c01631 ↗
39. 10.1016/j.snb.2022.13277010.1016/j.snb.2022.132770 ↗
40. 10.1016/j.jpha.2024.10108510.1016/j.jpha.2024.101085 ↗
41. 10.1002/anie.20241242010.1002/anie.202412420 ↗
42. 10.1021/acs.langmuir.4c0136810.1021/acs.langmuir.4c01368 ↗
43. 10.1186/s12889‐022‐13020‐310.1186/s12889‐022‐13020‐3 ↗
44. 10.1038/s41598‐025‐89178‐810.1038/s41598‐025‐89178‐8 ↗
45. 10.1021/acsnano.4c1123810.1021/acsnano.4c11238 ↗