Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety‐Like Behaviors

ABSTRACT The previous study elucidated that the C‐reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis‐associated anxiety‐like behaviors in rats. This molecular crosstalk along the periodontal‐hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several key issues remain to be further discussed regarding the establishment of the core finding linking peripheral inflammation to emotional disorders and potential translational significance. Here, this commentary analyzes the mechanisms underlying CRP entry into the brain, the choice of behavioral paradigms for emotional assessment, the possible dynamic evolution of the pathogenesis, and the translational potential of CRP, with the aim of fostering constructive academic discussion.