Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination (Adv. Sci. 33/2026)

Mechanoadaptation via Myosin Cytoplasmic Redistribution This illustration depicts the mechanoadaptation and self-protection mechanism of circulating tumor cells during hematogenous metastasis. Under harsh shearing, these non-adherent tumor cells redistribute myosin into cytoplasm to disrupt the interaction of actin with myosin and reduce force transmission and mechanosensitivity, enabling them to evade shear-induced death and eventually generate distal metastases. More details can be found in the Research Article by Youhua Tan, Baohua Ji, and co-workers (DOI: 10.1002/advs.202523112).