Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits (Adv. Sci. 33/2026)

Cryo-EM Structure Guided Engineering of Botulinum Neurotoxin A This futuristic cover depicts a golden magic hand for highlighting the engineering of botulinum neurotoxin type A. It illustrates that the structure-guided design optimizes wild-type toxin to enhance its receptor binding affinity, improve its therapeutic benefits, lower its diffusion from the local injection site, and increase safety for future clinical use. More details can be found in the Research Article by Dongsheng Wang, Dejuan Zhi, Dongsheng Lei and co-workers. (DOI: 10.1002/advs.202516713).