Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing
Source abstract
Abstract
ABSTRACT Composite magnetoelectric (piezoelectric/magnetostrictive) materials are gaining an increased interest due to their appealing wireless actuation capabilities. For many applications, such as sensing, energy harvesting or cell electrostimulation, flexible and adaptable heterostructures are required. However, some of the proposed structures suffer from poor magnetoelectric performance due to their inherent stiffness and the resulting substrate clamping effects. Here, a highly flexible and conformable nanostructured ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in a low Young's modulus elastomer (polydimethylsiloxane; PDMS) is presented. This heterostructure is designed to enhance wound healing via electric stimulation induced by low‐intensity and low‐frequency AC magnetic fields. In vitro testing using normal human dermal fibroblasts (NHDF) and human keratinocytes (HaCaT) cell cultures demonstrated high cell viability and no adverse effects under magnetoelectric stimulation. Moreover, the magnetoelectric stimulation significantly enhanced keratinocyte stratification and fibroblast collagen production, with remarkable improvements in cell migration compared to non‐stimulated cells. These results underscore the potential of highly flexible magnetoelectric heterostructures as active dressings to improve wound healing processes, especially relevant for chronic wounds and other epithelial disorders.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Advanced Sensor and Energy Harvesting Materials · Planarian Biology and Electrostimulation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST Bellaterra Barcelona Spain
Departament de Biologia Cel·lular, Fisiologia i Immunologia Universitat Autònoma de Barcelona Bellaterra Spain
Instituto de Microelectronica de Barcelona (IMB‐CNM, CSIC) Bellaterra Barcelona Spain
Multi‐Scale Robotics Lab (MSRL) Institute of Robotics and Intelligent Systems (IRIS) Zürich Switzerland
Center Odličnosti Nanoznanosti in Nanotehnologije Ljubljana Slovenia
Departament de Física Universitat Autònoma de Barcelona Bellaterra Spain
National Institute of Chemistry Ljubljana Slovenia
Department for Materials Synthesis Jožef Stefan Institute Ljubljana Slovenia
ICREA Bracelona Spain
International Institute for Intelligent Nanorobots and Nanosystems College of Intelligent Robotics and Advanced Manufacturing State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of Optoelectronics Fudan University Shanghai China
Zhejiang Key Laboratory of Extreme Environment Functional Materials Yiwu Research Institute of Fudan university Yiwu China
Funding
Staatssekretariat für Bildung, Forschung und Innovation · HORIZON EUROPE Excellent Science · Horizon 2020 · Agència de Gestió d'Ajuts Universitaris i de Recerca · Ministerio de Ciencia e Innovación
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