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journal article·2026-06-12Open access

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang

Advanced Science
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Abstract

ABSTRACT Ion release‐driven inflammation and bone loss underlie metallic implant failure. Here, micro‐galvanic coupling design of alloys electrochemically programs essential element releasing dose to modulate immune responses and promote regenerative healing. Using model alloys, finely dispersed Mg 2 Zn 11 particles in Zn‐0.8Mg act as sacrificial anodes, suppressing Zn matrix dissolution. In contrast, coarse FeZn 13 phases in Zn‐0.8Fe establish a “large cathode‐small anode” galvanic regime, elevating anodic current densities by two orders of magnitude. Consequently, Zn‐0.8Fe implants in bone marrow release excessive Zn 2+ , drive massive neutrophil recruitment and proinflammatory polarization (Day 3), and induce M1‐dominant macrophage responses (Day 14), culminating in poor bone formation at Day 90. Conversely, Zn‐0.8Mg releases a moderate Zn 2+ flux, promotes pro‐regenerative neutrophil polarization, and guides an M2‐dominant macrophage milieu that fosters osteogenesis rich in type I collagen. Findings here provide the composition design rationale for the development and translational application of a biodegradable Zn alloy cranio‐maxillofacial internal fixation system.
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Research context

Energy storageMetals & alloysBiomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Magnesium Alloys: Properties and Applications · Planarian Biology and Electrostimulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Engineering Medicine Beihang University Beijing China

Department of Joint Replacement, Sports Medicine, and Trauma,Department of Orthopedics, Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China

School of Materials Science and Engineering Peking University Beijing China

Department of Reproduction and Physiology National Research Institute For Family Planning Beijing China

Medical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China

Engineering Research Center of Bone and Joint Precision Medicine, Department of Orthopedics Peking University Third Hospital Beijing China

Department of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China

The Third Affiliated Hospital of Southern Medical University Southern Medical University Guangzhou Guangdong China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Fundamental Research Funds for the Central Universities · China Postdoctoral Science Foundation

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