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journal article·2026-06Open access

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology (Adv. Sci. 32/2026)

Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol

Advanced Science· Volume 13· Issue 32
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Source abstract

Abstract

Alzheimer's Disease The cover illustrates how ALKBH3 demethylates PINK1 mRNA at m1A sites, destabilizing PINK1 transcripts and suppressing mitophagy, which drives Alzheimer's pathology (winter scene). Restoring ALKBH3 function rescues mitophagy (spring scene), with PINK1 (pink flower) facilitating mitochondrial transport along neurites (branches). More details can be found in the Research Article by Magdalena J. Koziol and co-workers (DOI: 10.1002/advs.202522572). Image credit: Li Jiayue, Li Yueyang, and Mingje Dong.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: RNA modifications and cancer · Autophagy in Disease and Therapy · Epigenetics and DNA Methylation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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