Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis
Source abstract
Abstract
ABSTRACT Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy‐specific disorder characterized by elevated maternal serum total bile acid (TBA) and increased risk of adverse fetal outcomes, yet current therapies and preventive strategies remain suboptimal. Here, we present a preclinical investigation of nanocellulose as a gut microbiota‐targeted dietary intervention to restore bile acid homeostasis. We demonstrate that nanocellulose, particularly cellulose nanofibers (CNF), administered prophylactically, attenuated maternal TBA and improved offspring survival in a rat ICP model by enriching probiotic microbial taxa while suppressing bile acid‐transforming bacteria. These microbial shifts promoted the accumulation of fecal primary bile acids and activation of gut–liver farnesoid X receptor (FXR) signaling. This cascade reduced intestinal reabsorption and hepatic synthesis of bile acids while promoting their excretion in feces. Collectively, pre‐gestational CNF effectively lowered systemic bile acid burden and mitigated the ICP phenotype. Our findings identify CNF as a biosafe, microbiota‐responsive dietary fiber with translational potential for early preventive management of bile acid‐related disorders during pregnancy.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Drug Transport and Resistance Mechanisms · Gut microbiota and health · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Obstetrics and Gynecology The Second Affiliated Hospital of Chongqing Medical University Chongqing China
College of Food Science Southwest University Chongqing China
Department of Pathology from College of Basic Medicine Chongqing Medical University Chongqing China
Agilent Technology Guangzhou China
Environmental Research and Innovation Department Luxembourg Institute of Science and Technology Esch‐sur‐Alzette Luxembourg
Heart Research Institute The University of Sydney Newtown Australia
Department of Oral Sciences Sir John Walsh Research Institute Faculty of Dentistry University of Otago Dunedin New Zealand
Molecular Immunity Murdoch Children's Research Institute Royal Children's Hospital Melbourne Australia
Chongqing Academy of Agricultural Sciences Chongqing China
Funding
Chongqing Municipal Education Commission · Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Chongqing Municipal Health Commission
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